ArticleAntibiotics (Basel, Switzerland)2023
Early-Life Antibiotic Exposure and Childhood Asthma Trajectories: A National Population-Based Birth Cohort.
Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Antibiotic treatment for non-specific upper respiratory tract infections and exacerbation risk in children with asthma: a target trial emulation study.American journal of epidemiology · 2026Article
- Patterns of Antibiotic Dispensing Among New Zealand Children: A Linkage Study.Pharmacoepidemiology and drug safety · 2026Article
- The Impact of Early Childhood Caries on Asthma Trajectories During the First 15 Years of Life.Allergy · 2026Article
- Allergic but not autoimmune comorbidities in children with PFAPA: A nationwide matched case-control cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- ZIP8 loss impairs macrophage-mediated phagolysosomal removal of bacteria and is overcome by butyrate supplementation.Communications biology · 2026Article
- Gut-Lung Microbiota Axis Shapes the Immune Microenvironment and Immunotherapeutic Response in Lung Cancer.International journal of biological sciences · 2026Review
- Real-World Utility of the Host-Response MeMed BV Test in a Pediatric Emergency Department: A Non-Randomized Study with Optimized Antimicrobial and Diagnostic Stewardship.Children (Basel, Switzerland) · 2025Article
- Postnatal antibiotic exposure due to maternal group B streptococcus is associated with childhood asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Factors influencing biospecimen collection in decentralized pregnancy and birth cohorts: A qualitative study.Journal of clinical and translational science · 2025Article
- Innovative Therapeutic Strategies for Asthma: The Role of Gut Microbiome in Airway Immunity.Journal of asthma and allergy · 2025Review
- Parental perception of antibiotic use in children at home: a cross-sectional study.Revista brasileira de enfermagem · 2025Article
- Use of antibiotics in early life and development of diseases in childhood: nationwide registry study.BMJ medicine · 2025Article
- Short-chain fatty acids: linking diet, the microbiome and immunity.Nature reviews. Immunology · 2024Review
- Unraveling the Microbial Symphony: Impact of Antibiotics and Probiotics on Infant Gut Ecology and Antibiotic Resistance in the First Six Months of Life.Antibiotics (Basel, Switzerland) · 2024Article
- A Comprehensive Look at the Development of Asthma in Children.Children (Basel, Switzerland) · 2024Review
- Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study.Frontiers in allergy · 2024Article
- Gut dysbiosis mediates the association between antibiotic exposure and chronic disease.Frontiers in medicine · 2024Review
- The potential of live biotherapeutic products in allergic disease: current findings and future directions.Frontiers in microbiomes · 2024Review
- Winds of change a tale of: asthma and microbiome.Frontiers in microbiology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEarly-life antibiotic exposure is common and impacts the development of the child's microbiome and immune system. Information on the impacts of early-life antibiotics exposure on childhood asthma is lacking.
methodsThis study examined associations between early-life (0-24 months) antibiotics exposure with childhood (6-15 years) asthma trajectories through the Australian Longitudinal Study of Australian Children (LSAC) and their linked data from the Pharmaceutical Benefits Scheme. Asthma phenotypes were derived by group-based trajectory modeling.
resultsOf 5107 LSAC participants, 4318 were included in the final analyses (84.6% retention). Four asthma phenotypes were identified: Always-low-risk (79.0%), early-resolving asthma (7.1%), early-persistent asthma (7.9%), and late-onset asthma (6.0%). Any early-life antibiotic exposure increased risk 2.3-fold (95% CI: 1.47-3.67;
conclusionWe concluded that early-life antibiotic exposure is associated with an increased risk of early-persistent childhood asthma. This reinforces scrutiny of early-life antibiotic use, particularly for common viral infections where no antibiotics are required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.