ReviewAntibiotics (Basel, Switzerland)2023
The Impact of Care Bundles on Ventilator-Associated Pneumonia (VAP) Prevention in Adult ICUs: A Systematic Review.
Review in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 69 citations in OpenAlex.
- Bacterial Colonization of Silver-Additive Ventilator Circuit in Patients Receiving Mechanical Ventilation: A Randomized Controlled Trial.The clinical respiratory journal · 2025Trial
- Trial
- A National Collaborative Project to Decrease Healthcare-Associated Infections in Intensive Care Units: Results from Stop Hospital Infection, in Portugal.Antibiotics (Basel, Switzerland) · 2026Article
- Effects of Comprehensive Bundled Nursing Care on Psychological Disorders in Mechanically Ventilated Intensive Care Unit Patients.Actas espanolas de psiquiatria · 2026Article
- Article
- Prevention of Ventilator-Associated Pneumonia in Intensive Care Units: The Effect of Scenario-Based Simulation on Nursing Students' Skill Development Process.Nursing in critical care · 2026Article
- Ventilator-Associated Pneumonia (VAP) Prevention Bundle: A Multicenter Cross-Sectional Saudi Study to Assess Knowledge, Adherence, and Perceived Barriers Among ICU Practitioners in Hail Region.Pathogens (Basel, Switzerland) · 2026Article
- Patient Safety Implications of Opportunistic Pathogens and Healthcare-Associated Infections in COVID-19 Patients: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Infection Control and Prevention Awareness Among Intensive and Cardiac Care Nurses: Implications for Managers and Policymakers.Nursing open · 2026Article
- Epidemiology and Outcomes of Ventilator-Associated Pneumonia in Saudi Arabian Intensive Care Units: A Systematic Review and Meta-Analysis.Microorganisms · 2026Review
- Article
- Microbial signatures and host immune responses associated with the development of ventilator-associated pneumonia among patients with neurological injuries.Microbiology spectrum · 2026Article
- Perpetual observational study of the clinical and microbiological epidemiology of ventilator-associated pneumonia in Europe.Critical care (London, England) · 2026Observational
- Effect of the SAFE-CARE nursing bundle on artificial airway-related complications in adult ICU patients: a before-and-after interrupted time-series study.Frontiers in medicine · 2026Article
- Impact of Plan-Do-Study-Act Cycle-Based Quality Improvement on Head-of-Bed Elevation Compliance, Cuff Pressure Management and Ventilator-Associated Pneumonia in Intensive Care Units: A Before-After Study.Journal of multidisciplinary healthcare · 2026Article
- Ventilator-Associated Pneumonia (VAP) in Neurocritical Patients: The Hidden Dialog of Brain and Infection.Biomedicines · 2025Review
- Oropharyngeal Interventions in Intubated Patients for Preventing Ventilator Associated Pneumonia: A Systematic Review and Multi-Variate Network Meta-Analysis Evaluating Pharmacological Agents.Journal of clinical medicine · 2025Review
- Sustained effect of a multifaceted VAP prevention program over more than seven years including the COVID-19 pandemic.Antimicrobial resistance and infection control · 2025Article
- Article
- Evidence-Based Practices to Prevent Ventilator-Associated Pneumonia in an Intensive Care Unit in Bangladesh.Healthcare (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ventilator-associated pneumonia (VAP) remains a common risk in mechanically ventilated patients. Different care bundles have been proposed to succeed VAP reduction. We aimed to identify the combined interventions that have been used to by ICUs worldwide from the implementation of "Institute for Healthcare Improvement Ventilator Bundle", i.e., from December 2004. A search was performed on the PubMed, Scopus and Science Direct databases. Finally, 38 studies met our inclusion criteria. The most common interventions monitored in the care bundles were sedation and weaning protocols, semi-recumbent positioning, oral and hand hygiene, peptic ulcer disease and deep venus thrombosis prophylaxis, subglottic suctioning, and cuff pressure control. Head-of-bed elevation was implemented by almost all studies, followed by oral hygiene, which was the second extensively used intervention. Four studies indicated a low VAP reduction, while 22 studies found an over 36% VAP decline, and in ten of them, the decrease was over 65%. Four of these studies indicated zero or nearly zero after intervention VAP rates. The studies with the highest VAP reduction adopted the "IHI Ventilator Bundle" combined with adequate endotracheal tube cuff pressure and subglottic suctioning. Multifaced techniques can lead to VAP reduction at a great extent. Multidisciplinary measures combined with long-lasting education programs and measurement of bundle's compliance should be the gold standard combination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.