Evidence map›Paper›PMID 36830036›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Antioxidant Strategies to Modulate NETosis and the Release of Neutrophil Extracellular Traps during Chronic Inflammation.

Line A E Hallberg, Kristine Barlous, Clare L Hawkins

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Standardized Extract of Flavonoids fromJournal of inflammation research · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Neutrophil extracellular traps: a catalyst for atherosclerosis.Molecular and cellular biochemistry · 2024
    Review
  12. (Chemical) Roles of HOCl in Rheumatic Diseases.Antioxidants (Basel, Switzerland) · 2024
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Line A E HallbergDepartment of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.ORCID 0000-0001-6901-3449
Kristine BarlousDepartment of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Clare L HawkinsDepartment of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.ORCID 0000-0003-2738-5089
University of Copenhagen · DK

Funding

Novo Nordisk Foundation NNF17OC0028990Royal Society of Chemistry R21-4699728863
6 · The paper itself

Abstract

Extracellular traps are released by neutrophils and other immune cells as part of the innate immune response to combat pathogens. Neutrophil extracellular traps (NETs) consist of a mesh of DNA and histone proteins decorated with various anti-microbial granule proteins, such as elastase and myeloperoxidase (MPO). In addition to their role in innate immunity, NETs are also strongly linked with numerous pathological conditions, including atherosclerosis, sepsis and COVID-19. This has led to significant interest in developing strategies to inhibit NET release. In this study, we have examined the efficacy of different antioxidant approaches to selectively modulate the inflammatory release of NETs. PLB-985 neutrophil-like cells were shown to release NETs on exposure to phorbol myristate acetate (PMA), hypochlorous acid or nigericin, a bacterial peptide derived from

Indexed as

chronic inflammationhypochlorous acidmyeloperoxidaseneutrophilneutrophil extracellular trapselenocyanateTEMPOthiocyanate

Identifiers

PMID36830036
PMCPMC9952818
OpenAlexW4320728515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.