Evidence map›Paper›PMID 36830033›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability.

Kit-Kay Mak, Zhang Shiming, Raghavendra Sakirolla, Madhu Katyayani Balijepalli, Albena T Dinkova-Kostova, Ola Epemolu, Zulkefeli Mohd, Mallikarjuna Rao Pichika

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Kit-Kay MakDepartment of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.ORCID 0000-0001-6939-5280
Zhang ShimingSchool of Postgraduate Studies, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.
Raghavendra SakirollaDepartment of Chemistry, Central University of Karnataka, Gulbarga 585367, Karnataka, India.
Madhu Katyayani BalijepalliDepartment of Pharmacology, Faculty of Medicine, Bioscience & Nursing, MAHSA University, Jln SP 2, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia.
Albena T Dinkova-KostovaDivision of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, University of Dundee, Dundee DD1 4HN, UK.ORCID 0000-0003-0316-9859
Ola EpemoluPrincipal Research Scientist-In Vitro/In Vivo DMPK, Charles River Laboratories Edinburgh Ltd., Tranent EH33 2NE, UK.
Zulkefeli MohdDepartment of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.ORCID 0000-0001-9852-7238
Mallikarjuna Rao PichikaDepartment of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Selangor, Malaysia.
IMU University · MYCentral University of Karnataka · INCharles River Laboratories (United Kingdom) · GBJohns Hopkins University · USMahsa University · MY

Funding

International Medical University, Malaysia PMHS I-2018 (02)Ministry of Higher Education FRGS/1/2018/WAB13/MAHSA/02/1
6 · The paper itself

Abstract

6-shogaol is a natural and the most potent bioactive vanilloid in dried

Indexed as

6-shogaolanti-inflammatory activitymicrosomal stabilitymolecular dockingNRF2thiophene derivativesZingiber officinale

Identifiers

PMID36830033
PMCPMC9951879
OpenAlexW4320728451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.