ReviewAntioxidants (Basel, Switzerland)2023
Oxidative Stress in Depression: The Link with the Stress Response, Neuroinflammation, Serotonin, Neurogenesis and Synaptic Plasticity.
Review in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
182 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Adherence to the EAT-Lancet diet and neuropsychiatric disorders: a systematic review and meta-analysis.Psychological medicine · 2026Pooled it
- Depression increases cancer mortality by 23-83%: a meta-analysis of 65 studies across five major cancer types.GeroScience · 2026Pooled it
- TNF-α levels in first-episode, drug-naïve patients with major depressive disorder: a case-control study and meta-analysis.BMC psychiatry · 2026Pooled it
- Research trends and hotspots of electroacupuncture for depression: a bibliometric and visual analysis (2005-2025).Frontiers in psychiatry · 2026Pooled it
- Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies.Psychopharmacology · 2025Pooled it
- From Mind to Milk: The Influence of Psychological Factors on the Composition of Human Breast Milk.Nutrients · 2025Pooled it
- The biological relationship among depression, vitamins BFrontiers in nutrition · 2025Pooled it
- Curcumin Reduces Depression in Obese Patients with Type 2 Diabetes: A Randomized Controlled Trial.Nutrients · 2024Trial
- Natural medicine‑empowered treatment of depression via restoring neurogenesis (Review).Molecular medicine reports · 2026Review
- Adaptogenic-Like Potential of Bauhinia forficata Leaf Extracts: Behavioral and Oxidative Outcomes in an Acute Stress Mouse Model.Brain and behavior · 2026Article
- Effects of sex, treatment resistance, and antidepressant treatment on monoamine oxidase B total distribution volume.medRxiv : the preprint server for health sciences · 2026Article
- Metabolic shifts driven by host-microbial interactions.The FEBS journal · 2026Review
- From adolescence to Alzheimer's: a neurodevelopmental lifespan model of cognitive vulnerability.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Sulforaphane mitigates behavioral deficits in experimental chronic kidney disease through regulation of Nrf2/NLRP3 inflammasome.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Antidepressant-like Effects ofMolecules (Basel, Switzerland) · 2026Article
- Effects of crocin on anxiety, depression, and hippocampal BDNF expression in streptozotocin-induced diabetic rats.Annals of medicine and surgery (2012) · 2026Article
- Integrated biomarkers of oxidative stress NLRP3 inflammasome and kynurenine pathway reflect disease severity and diagnostic discrimination in depression.Scientific reports · 2026Article
- NAD⁺ biology and supplementation: From mechanisms to clinical perspectives.Molecular biology reports · 2026Review
- Article
- A Pilot Randomized, Double-Blind, Placebo-Controlled Parallel Group Trial Evaluating the Effect of 8 Week-Consumption of Guava Jelly Drink in Improving Cognition and Mental Well-Being in Working-Age Adults.Foods (Basel, Switzerland) · 2026Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a prevalent, complex, and highly debilitating disease. The full comprehension of this disease is still a global challenge. Indeed, relapse, recurrency, and therapeutic resistance are serious challenges in the fight against depression. Nevertheless, abnormal functioning of the stress response, inflammatory processes, neurotransmission, neurogenesis, and synaptic plasticity are known to underlie the pathophysiology of this mental disorder. The role of oxidative stress in disease and, particularly, in depression is widely recognized, being important for both its onset and development. Indeed, excessive generation of reactive oxygen species and lack of efficient antioxidant response trigger processes such as inflammation, neurodegeneration, and neuronal death. Keeping in mind the importance of a detailed study about cellular and molecular mechanisms that are present in depression, this review focuses on the link between oxidative stress and the stress response, neuroinflammation, serotonergic pathways, neurogenesis, and synaptic plasticity's imbalances present in depression. The study of these mechanisms is important to lead to a new era of treatment and knowledge about this highly complex disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.