Evidence map›Paper›PMID 36830012›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Plasma Copper Concentration Is Associated with Cardiovascular Mortality in Male Kidney Transplant Recipients.

Manuela Yepes-Calderón, Daan Kremer, Adrian Post, Camilo G Sotomayor, Ulrike Seidel, Patricia Huebbe, Tim J Knobbe, Kai Lüersen, Michele F Eisenga, Eva Corpeleijn and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 2 countries.

Manuela Yepes-CalderónDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-4693-5974
Daan KremerDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-0011-115X
Adrian PostDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-8645-1627
Camilo G SotomayorDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-6835-6386
Ulrike SeidelInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany.ORCID 0000-0003-4384-488X
Patricia HuebbeInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany.
Tim J KnobbeDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-3246-3192
Kai LüersenInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany.ORCID 0000-0001-5812-1196
Michele F EisengaDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-2484-6233
Eva CorpeleijnDepartment of Epidemiology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Martin H De BorstDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-4127-8733
Gerjan J NavisDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Gerald RimbachInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany.ORCID 0000-0001-7888-4684
Stephan J L BakkerDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-3356-6791
University Medical Center Groningen · NL

Funding

TiFN A-1003
6 · The paper itself

Abstract

Kidney transplant recipients (KTR) are at increased risk of cardiovascular mortality. We investigated whether, in KTR, post-transplantation copper status is associated with the risk of cardiovascular mortality and potential effect modification by sex. In this cohort study, plasma copper was measured using mass spectrometry in extensively-phenotyped KTR with a functioning allograft >1-year. Cox regression analyses with the inclusion of multiplicative interaction terms were performed. In 660 KTR (53 ± 13 years old, 56% male), the median baseline plasma copper was 15.42 (IQR 13.53-17.63) µmol/L. During a median follow-up of 5 years, 141 KTR died, 53 (38%) due to cardiovascular causes. Higher plasma copper was associated with an increased risk of cardiovascular mortality in the overall KTR population (HR 1.37; 95% CI, 1.07-1.77 per 1-SD,

Indexed as

cardiovascularcopperkidney transplantationmortality

Identifiers

PMID36830012
PMCPMC9952822
OpenAlexW4320496912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.