Evidence map›Paper›PMID 36830006›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis.

Ying Chen, Katherine D Holland, Howard G Shertzer, Daniel W Nebert, Timothy P Dalton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Gene-dose effect of the glutathione biosynthesis gene on ascorbate deficiency in mice.Biochemical and biophysical research communications · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ying ChenDepartment of Environmental and Public Health Sciences, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Katherine D HollandDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Howard G ShertzerDepartment of Environmental and Public Health Sciences, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Daniel W NebertDepartment of Environmental and Public Health Sciences, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Timothy P DaltonDepartment of Environmental and Public Health Sciences, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
University of Cincinnati Medical Center · USCincinnati Children's Hospital Medical Center · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Redox Regulation of O-GlcNAcylation Signaling in the Pathogenesis of Alcoholic Fatty Liver DiseaseR01AA028859 · NIAAA · YALE UNIVERSITY · PI Ying Chen · 2022 to 2026
$1.9M
Glutathione in Environmental Toxicity and DiseaseR01ES012463 · NIEHS · UNIVERSITY OF CINCINNATI · PI SHERTZER, HOWARD · 2003 to 2007
$1.6M
Novel Redox-Associated Mechanisms Preventing Alcoholic Fatty LiverK01AA025093 · NIAAA · YALE UNIVERSITY · PI CHEN, YING · 2016 to 2019
$702k
National Institute of Health R01ES012463, P30ES06096, K01AA025093, R01AA028859NIAAA NIH HHS K01 AA025093NIAAA NIH HHS R01 AA028859NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R01 ES012463
6 · The paper itself

Abstract

Reduced glutathione (GSH) and ascorbic acid (AA) are the two most abundant low-molecular-weight antioxidants in mammalian tissues.

Indexed as

ascorbic acidepilepsyglutamatergic neurotransmissionglutathioneoxidative stress

Identifiers

PMID36830006
PMCPMC9952205
OpenAlexW4319964827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.