Evidence map›Paper›PMID 36829775›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Inside the Mechanism of Action of Three Pyrazole Derivatives in Human Platelets and Endothelial Cells.

Chiara Brullo, Eleonora Russo, Silvano Garibaldi, Paola Altieri, Pietro Ameri, Silvia Ravera, Maria Grazia Signorello

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Targeting the p53/xCT/GSH Axis with PRIMA-1International journal of molecular sciences · 2025
    Article
  4. Article
  5. Article
  6. Amino-Pyrazoles in Medicinal Chemistry: A Review.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chiara BrulloDepartment of Pharmacy, Section of Medicinal Chemistry, University of Genova, 16132 Genova, Italy.ORCID 0000-0002-2575-7726
Eleonora RussoDepartment of Pharmacy, Section of Medicinal Chemistry, University of Genova, 16132 Genova, Italy.ORCID 0000-0002-5856-7929
Silvano GaribaldiDepartment of Internal Medicine, University of Genova, 16132 Genova, Italy.
Paola AltieriDepartment of Internal Medicine, University of Genova, 16132 Genova, Italy.
Pietro AmeriDepartment of Internal Medicine, University of Genova, 16132 Genova, Italy.
Silvia RaveraDepartment of Experimental Medicine, University of Genova, 16132 Genova, Italy.ORCID 0000-0002-0803-1042
Maria Grazia SignorelloDepartment of Pharmacy, Biochemistry Lab, University of Genova, 16132 Genova, Italy.
University of Genoa · ITOspedale Policlinico San Martino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the effort to obtain multitarget compound interfering with inflammation, oxidative stress, and tumorigenesis, we synthesized a small library of pyrazole compounds, selecting

Indexed as

antiproliferative activityendothelial cellshuman plateletsinflammationoxidative phosphorylationoxidative stresspyrazole

Identifiers

PMID36829775
PMCPMC9952262
OpenAlexW4317393615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.