Evidence map›Paper›PMID 36829752›Full record

ReviewBioengineering (Basel, Switzerland)2023

Protective Role and Functional Engineering of Neuropeptides in Depression and Anxiety: An Overview.

Nathalie Okdeh, Georges Mahfouz, Julien Harb, Jean-Marc Sabatier, Rabih Roufayel, Eddie Gazo Hanna, Hervé Kovacic, Ziad Fajloun

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Nathalie OkdehDepartment of Biology, Faculty of Sciences 3, Campus Michel Slayman Ras Maska, Lebanese University, Tripoli 1352, Lebanon.ORCID 0000-0002-7288-7267
Georges MahfouzDepartment of Psychology, Faculty of Arts and Sciences, Beirut Campus, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.
Julien HarbFaculty of Medicine and Medical Sciences, Dekouene Campus, University of Balamand, Sin El Fil 55251, Lebanon.
Jean-Marc SabatierCNRS, INP, Inst Neurophysiopathol, Aix-Marseille Université, 13385 Marseille, France.ORCID 0000-0002-9040-5647
Rabih RoufayelCollege of Engineering and Technology, American University of the Middle East, Egaila 54200, Kuwait.ORCID 0000-0002-4595-1104
Eddie Gazo HannaCollege of Engineering and Technology, American University of the Middle East, Egaila 54200, Kuwait.
Hervé KovacicCNRS, INP, Inst Neurophysiopathol, Aix-Marseille Université, 13385 Marseille, France.ORCID 0000-0001-6509-4210
Ziad FajlounDepartment of Biology, Faculty of Sciences 3, Campus Michel Slayman Ras Maska, Lebanese University, Tripoli 1352, Lebanon.ORCID 0000-0002-6502-3110
American University of the Middle East · KWCentre National de la Recherche Scientifique · FRLebanese University · LBAmerican University of Beirut · LBUniversity of Balamand · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Behavioral disorders, such as anxiety and depression, are prevalent globally and touch children and adults on a regular basis. Therefore, it is critical to comprehend how these disorders are affected. It has been demonstrated that neuropeptides can influence behavior, emotional reactions, and behavioral disorders. This review highlights the majority of the findings demonstrating neuropeptides' behavioral role and functional engineering in depression and anxiety. Gut-brain peptides, hypothalamic releasing hormone peptides, opioid peptides, and pituitary hormone peptides are the four major groups of neuropeptides discussed. Some neuropeptides appear to promote depression and anxiety-like symptoms, whereas others seem to reduce it, all depending on the receptors they are acting on and on the brain region they are localized in. The data supplied here are an excellent starting point for future therapy interventions aimed at treating anxiety and depression.

Indexed as

anxietydepressiongut–brain peptideneuropeptidesopioid peptidepituitary hormone peptide

Identifiers

PMID36829752
PMCPMC9952193
OpenAlexW4321095137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.