Evidence map›Paper›PMID 36829708›Full record

ArticleBioengineering (Basel, Switzerland)2023

Peptides in Dentistry: A Scoping Review.

Louis Hardan, Jean Claude Abou Chedid, Rim Bourgi, Carlos Enrique Cuevas-Suárez, Monika Lukomska-Szymanska, Vincenzo Tosco, Ana Josefina Monjarás-Ávila, Massa Jabra, Fouad Salloum-Yared, Naji Kharouf and 2 more

Open access · goldAbstract readScoping Review
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 7 countries.

Louis HardanDepartment of Restorative Dentistry, School of Dentistry, Saint Joseph University, Beirut 1107 2180, Lebanon.ORCID 0000-0001-8577-2285
Jean Claude Abou ChedidDepartment of Pediatric Dentistry, Faculty of Dentistry, Saint Joseph University, Beirut 1107 2180, Lebanon.
Rim BourgiDepartment of Restorative Dentistry, School of Dentistry, Saint Joseph University, Beirut 1107 2180, Lebanon.ORCID 0000-0002-8003-2664
Carlos Enrique Cuevas-SuárezDental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, San Agustín Tlaxiaca 42160, Mexico.ORCID 0000-0002-2759-8984
Monika Lukomska-SzymanskaDepartment of General Dentistry, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland.ORCID 0000-0002-6110-4298
Vincenzo ToscoDepartment of Clinical Sciences and Stomatology (DISCO), Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0002-3378-3844
Ana Josefina Monjarás-ÁvilaDental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, San Agustín Tlaxiaca 42160, Mexico.ORCID 0000-0002-5916-6510
Massa JabraFaculty of Medicine, Damascus University, Damascus 0100, Syria.
Fouad Salloum-YaredPrivate Practice, 54290 Trier, Germany.
Naji KharoufDepartment of Biomaterials and Bioengineering, INSERM UMR_S 1121, University of Strasbourg, 67000 Strasbourg, France.ORCID 0000-0001-6768-138X
Davide MancinoDepartment of Biomaterials and Bioengineering, INSERM UMR_S 1121, University of Strasbourg, 67000 Strasbourg, France.ORCID 0000-0001-7376-371X
Youssef HaikelDepartment of Biomaterials and Bioengineering, INSERM UMR_S 1121, University of Strasbourg, 67000 Strasbourg, France.
Inserm · FRSaint Joseph University · LBUniversidad Autónoma del Estado de Hidalgo · MXDamascus University · SYMarche Polytechnic University · ITMedical University of Lodz · PLTrier University of Applied Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, it remains unclear which specific peptides could be appropriate for applications in different fields of dentistry. The aim of this scoping review was to scan the contemporary scientific papers related to the types, uses and applications of peptides in dentistry at the moment. Literature database searches were performed in the following databases: PubMed/MEDLINE, Scopus, Web of Science, Embase, and Scielo. A total of 133 articles involving the use of peptides in dentistry-related applications were included. The studies involved experimental designs in animals, microorganisms, or cells; clinical trials were also identified within this review. Most of the applications of peptides included caries management, implant osseointegration, guided tissue regeneration, vital pulp therapy, antimicrobial activity, enamel remineralization, periodontal therapy, the surface modification of tooth implants, and the modification of other restorative materials such as dental adhesives and denture base resins. The in vitro and in vivo studies included in this review suggested that peptides may have beneficial effects for treating early carious lesions, promoting cell adhesion, enhancing the adhesion strength of dental implants, and in tissue engineering as healthy promotors of the periodontium and antimicrobial agents. The lack of clinical trials should be highlighted, leaving a wide space available for the investigation of peptides in dentistry.

Indexed as

antimicrobialosseointegrationsurface modificationtissue engineering

Identifiers

PMID36829708
PMCPMC9952573
OpenAlexW4319296686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.