ReviewBioengineering (Basel, Switzerland)2023
A Review of 3D Polymeric Scaffolds for Bone Tissue Engineering: Principles, Fabrication Techniques, Immunomodulatory Roles, and Challenges.
Review in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immunomodulatory Tissue-Engineering Strategies for Diabetic Foot Ulcer Management: A Systematic Review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
- Electroconductive and biodegradable scaffold based on alginate/polyaniline hydrogel loaded with green synthesized magnesium oxide nanoparticles for bone regeneration.Cell and tissue banking · 2026Article
- HAp/PLGA/Chitosan Scaffolds Fabricated by Freeze-Drying and 3D Printing for Bone Regeneration: In Vitro Evaluation and Finite Element Analysis.Biomimetics (Basel, Switzerland) · 2026Article
- Biochemical and Physicomechanical Cues of Biomaterials Guide Osteogenic Differentiation of Mesenchymal Stem Cells.International journal of molecular sciences · 2026Review
- Bioactive Natural Compounds: A Review of Their Integration into Bone Tissue Engineering Scaffolds.Annals of biomedical engineering · 2026Review
- From Nature to Innovation: Exploring Natural Biopolymers in 3D Bioprinting for Bone Regeneration.ACS omega · 2026Article
- Bioinspired and living multiscale composites for regenerative medicine in the treatment of surgical site infections.Journal of nanobiotechnology · 2026Review
- From bone replacement to regeneration. A biomaterials started journey.Materials today. Bio · 2026Review
- Numerical Simulation of Bone Defect Repair Using a Triply Periodic Minimal Surface Scaffold.Journal of functional biomaterials · 2026Article
- Friedelin Enhances Gelatin/Nanohydroxyapatite Scaffold Performance by Inhibiting Osteoclastogenesis and Promoting Osteogenesis.ACS omega · 2026Article
- Plant-Based Scaffolds in Tissue Engineering: Structure-Function, Processing, and Clinical Outlook-A Review.Annals of biomedical engineering · 2026Review
- Scaffold Design: A Review of Material and Immune Modulation in Bone Tissue Engineering.Cell and tissue banking · 2026Review
- Unveiling the potential of inorganic nanoparticle-based scaffolds in wound healing: advances in antimicrobial and regenerative strategies.Nanoscale advances · 2026Review
- Versatility of Collagen as a Natural Biopolymer for Biomedical, Food, and Cosmetic Applications.Current protein & peptide science · 2026Review
- Xeno-Free Biocompatible Peptide-Based Bioinks Reinforced with Cellulose Nanofibers for 3D Printing.Advanced healthcare materials · 2026Article
- Recent Advancements in Non-surgical Approaches for the Management of Delayed Union and Nonunion in Long Bone Fractures of the Extremities: A Review.Advances in therapy · 2026Review
- Potential of organ-on-a-chip in advancing synthetic extracellular matrix technology for bone tissue engineering in dentistry (Review).Biomedical reports · 2026Review
- A prospective randomized split-mouth trial comparing immediate versus early anterior implant placement with customized healing abutments: 12-month marginal bone loss, stability, and esthetic outcome.Frontiers in dental medicine · 2026Article
- Article
- Development and Characterization of Biodegradable Polymer Filaments for Additive Manufacturing.Polymers · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last few years, biopolymers have attracted great interest in tissue engineering and regenerative medicine due to the great diversity of their chemical, mechanical, and physical properties for the fabrication of 3D scaffolds. This review is devoted to recent advances in synthetic and natural polymeric 3D scaffolds for bone tissue engineering (BTE) and regenerative therapies. The review comprehensively discusses the implications of biological macromolecules, structure, and composition of polymeric scaffolds used in BTE. Various approaches to fabricating 3D BTE scaffolds are discussed, including solvent casting and particle leaching, freeze-drying, thermally induced phase separation, gas foaming, electrospinning, and sol-gel techniques. Rapid prototyping technologies such as stereolithography, fused deposition modeling, selective laser sintering, and 3D bioprinting are also covered. The immunomodulatory roles of polymeric scaffolds utilized for BTE applications are discussed. In addition, the features and challenges of 3D polymer scaffolds fabricated using advanced additive manufacturing technologies (rapid prototyping) are addressed and compared to conventional subtractive manufacturing techniques. Finally, the challenges of applying scaffold-based BTE treatments in practice are discussed in-depth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.