Evidence map›Paper›PMID 36829691›Full record

ArticleBioengineering (Basel, Switzerland)2023

The Medium Obtained from the Culture of Hodgkin Lymphoma Cells Affects the Biophysical Characteristics of a Fibroblast Cell Model.

Maura Rossi, Francesco Alviano, Barie Myrtaj, Silvia Zia, Simona Righi, Valeria Pizzuti, Francesca Paris, Barbara Roda, Andrea Zattoni, Laura Bonsi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Maura RossiDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
Francesco AlvianoDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-5315-0104
Barie MyrtajDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
Silvia ZiaStem Sel srl, 40127 Bologna, Italy.
Simona RighiDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
Valeria PizzutiDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-5591-7663
Francesca ParisDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-0424-9287
Barbara RodaStem Sel srl, 40127 Bologna, Italy.ORCID 0000-0003-1060-2921
Andrea ZattoniStem Sel srl, 40127 Bologna, Italy.ORCID 0000-0001-6971-5360
Laura BonsiDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
Elena SabattiniHaematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-4136-3591
Claudio AgostinelliDepartment of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.
University of Bologna · ITAzienda USL di Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neoplastic Hodgkin-Reed-Sternberg (HRS) cells in Hodgkin lymphoma (HL) represent only 1-10% of cells and are surrounded by an inflammatory microenvironment. The HL cytokine network is a key point for the proliferation of HRS cells and for the maintenance of an advantageous microenvironment for HRS survival. In the tumor microenvironment (TME), the fibroblasts are involved in crosstalk with HRS cells. The aim of this work was to study the effect of lymphoma cell conditioned medium on a fibroblast cell population and evaluate modifications of cell morphology and proliferation. Hodgkin lymphoma-derived medium was used to obtain a population of "conditioned" fibroblasts (WS-1 COND). Differences in biophysical parameters were detected by the innovative device Celector

Indexed as

3D modelcell culturefibroblastsHodgkin lymphomalymphomatumor microenvironment

Identifiers

PMID36829691
PMCPMC9952528
OpenAlexW4319081996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.