Evidence map›Paper›PMID 36829526›Full record

ArticleBiology2023

Cumulus Cell Transcriptome after Cumulus-Oocyte Complex Exposure to Nanomolar Cadmium in an In Vitro Animal Model of Prepubertal and Adult Age.

Nicola Antonio Martino, Ernesto Picardi, Elena Ciani, Anna Maria D'Erchia, Luisa Bogliolo, Federica Ariu, Antonella Mastrorocco, Letizia Temerario, Luigi Mansi, Valeria Palumbo and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Frontiers in veterinary science · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Nicola Antonio MartinoDepartment of Biosciences, Biotechnologies & Environment, University of Bari Aldo Moro, Via Edoardo Orabona, 70125 Bari, Italy.ORCID 0000-0001-6853-2757
Ernesto PicardiDepartment of Biosciences, Biotechnologies & Environment, University of Bari Aldo Moro, Via Edoardo Orabona, 70125 Bari, Italy.ORCID 0000-0002-6549-0114
Elena CianiDepartment of Biosciences, Biotechnologies & Environment, University of Bari Aldo Moro, Via Edoardo Orabona, 70125 Bari, Italy.ORCID 0000-0001-5673-0975
Anna Maria D'ErchiaDepartment of Biosciences, Biotechnologies & Environment, University of Bari Aldo Moro, Via Edoardo Orabona, 70125 Bari, Italy.
Luisa BoglioloDepartment of Veterinary Medicine, University of Sassari, Via Vienna n. 2, 07100 Sassari, Italy.ORCID 0000-0003-3205-7362
Federica AriuDepartment of Veterinary Medicine, University of Sassari, Via Vienna n. 2, 07100 Sassari, Italy.
Antonella MastroroccoDepartment of Biosciences, Biotechnologies & Environment, University of Bari Aldo Moro, Via Edoardo Orabona, 70125 Bari, Italy.ORCID 0000-0001-7136-4029
Letizia TemerarioDepartment of Biosciences, Biotechnologies & Environment, University of Bari Aldo Moro, Via Edoardo Orabona, 70125 Bari, Italy.
Luigi MansiDepartment of Biosciences, Biotechnologies & Environment, University of Bari Aldo Moro, Via Edoardo Orabona, 70125 Bari, Italy.ORCID 0000-0001-8892-0423
Valeria PalumboDepartment of Biosciences, Biotechnologies & Environment, University of Bari Aldo Moro, Via Edoardo Orabona, 70125 Bari, Italy.ORCID 0000-0001-7756-6676
Graziano PesoleDepartment of Biosciences, Biotechnologies & Environment, University of Bari Aldo Moro, Via Edoardo Orabona, 70125 Bari, Italy.ORCID 0000-0003-3663-0859
Maria Elena Dell'AquilaDepartment of Biosciences, Biotechnologies & Environment, University of Bari Aldo Moro, Via Edoardo Orabona, 70125 Bari, Italy.
University of Bari Aldo Moro · ITUniversity of Sassari · IT

Funding

Italian Ministry of Health, Young Researchers Grant 2011/2012 GR-2011-02351396
6 · The paper itself

Abstract

Cadmium (Cd), a highly toxic pollutant, impairs oocyte fertilization, through oxidative damage on cumulus cells (CCs). This study analysed the transcriptomic profile of CCs of cumulus-oocyte complexes (COCs) from adult and prepubertal sheep, exposed to Cd nanomolar concentration during in vitro maturation. In both age-groups, CCs of matured oocytes underwent RNA-seq, data analysis and validation. Differentially expressed genes (DEGs) were identified in adult (

Indexed as

adult sheepcadmiumcumulus cellendocrine disrupting chemicalsfemale reproductive toxicitynon-invasive biomarkeroocyte competenceprepubertal lambRNA-sequencingtranscriptome

Identifiers

PMID36829526
PMCPMC9953098
OpenAlexW4319317422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.