Evidence map›Paper›PMID 36829450›Full record

ArticleBiology2023

Selective Destabilization of Transcripts by mRNA Decapping Regulates Oocyte Maturation and Innate Immunity Gene Expression during Ageing in

Fivos Borbolis, Dimitra Ranti, Maria-Despina Papadopoulou, Sofia Dimopoulou, Apostolos Malatras, Ioannis Michalopoulos, Popi Syntichaki

Open access · goldAbstract read
In one paragraph

Article in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fivos BorbolisCenter of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.ORCID 0000-0001-6559-1356
Dimitra RantiCenter of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.ORCID 0000-0002-8693-5207
Maria-Despina PapadopoulouCenter of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Sofia DimopoulouCenter of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Apostolos MalatrasCenter of Systems Biology, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.ORCID 0000-0003-1380-5521
Ioannis MichalopoulosCenter of Systems Biology, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.ORCID 0000-0001-8991-8712
Popi SyntichakiCenter of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.ORCID 0000-0001-9536-8905
Biomedical Research Foundation of the Academy of Athens · GR

Funding

European Research Council ERC grant agreement no. 201975Fondation Santé PS 2018
6 · The paper itself

Abstract

Removal of the 5' cap structure of RNAs (termed decapping) is a pivotal event in the life of cytoplasmic mRNAs mainly catalyzed by a conserved holoenzyme, composed of the catalytic subunit DCP2 and its essential cofactor DCP1. While decapping was initially considered merely a step in the general 5'-3' mRNA decay, recent data suggest a great degree of selectivity that plays an active role in the post-transcriptional control of gene expression, and regulates multiple biological functions. Studies in

Indexed as

ageingC. elegansDCAP-1innate immunitymicroarraymRNA decappingpolyglutaminePQM-1spermatogenesis

Identifiers

PMID36829450
PMCPMC9952881
OpenAlexW4317733671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.