Evidence map›Paper›PMID 36829442›Full record

ReviewBiology2023

The Gut Microbiota in Kidney Transplantation: A Target for Personalized Therapy?

Yuselys García-Martínez, Margherita Borriello, Giovanna Capolongo, Diego Ingrosso, Alessandra F Perna

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06825117 (Impact of Probiotic Supplementation on Urinary Tract Infections and Clinically Relevant Outcomes of Kidney Transplant Recipients), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06825117 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Impact of Probiotic Supplementation on Urinary Tract Infections and Clinically Relevant Outcomes of Kidney Transplant Recipients

TypeinterventionalSponsorUniversity Hospital, Udine, ItalyRan2024 to 2028Enrolled132ConditionsUrinary Tract Infections, Kidney Transplant Rejection, Kidney Transplant Infection, DysbiosisArmsOMNi-BiOTiC® 41167, Placebo
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  7. Review
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  9. Article
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  11. Review
  12. Article
  13. Review
  14. Article
  15. Kidney transplantation and gut microbiota.Clinical kidney journal · 2024
    Review
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yuselys García-MartínezDepartment of Translational Medical Science, University of Campania "Luigi Vanvitelli", Via Pansini, Bldg 17, 80131 Naples, Italy.ORCID 0000-0002-4184-6219
Margherita BorrielloDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Via L. De Crecchio 7, 80138 Naples, Italy.
Giovanna CapolongoDepartment of Translational Medical Science, University of Campania "Luigi Vanvitelli", Via Pansini, Bldg 17, 80131 Naples, Italy.
Diego IngrossoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Via L. De Crecchio 7, 80138 Naples, Italy.
Alessandra F PernaDepartment of Translational Medical Science, University of Campania "Luigi Vanvitelli", Via Pansini, Bldg 17, 80131 Naples, Italy.ORCID 0000-0003-4048-9392
University of Campania "Luigi Vanvitelli" · IT

Funding

European Union's Horizon 2020 research and innovation program, project STRATEGY-CKD 860329
6 · The paper itself

Abstract

Kidney transplantation improves quality of life, morbidity, and mortality of patients with kidney failure. However, integrated immunosuppressive therapy required to preserve graft function is associated with the development of post-transplant complications, including infections, altered immunosuppressive metabolism, gastrointestinal toxicity, and diarrhea. The gut microbiota has emerged as a potential therapeutic target for personalizing immunosuppressive therapy and managing post-transplant complications. This review reports current evidence on gut microbial dysbiosis in kidney transplant recipients, alterations in their gut microbiota associated with kidney transplantation outcomes, and the application of gut microbiota intervention therapies in treating post-transplant complications.

Indexed as

allograft rejectiondiarrheagut microbiotaimmunosuppressive therapykidney transplantationpost-transplant infection

Identifiers

PMID36829442
PMCPMC9952448
OpenAlexW4317621287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.