Evidence map›Paper›PMID 36829258›Full record

ArticleEuropean journal of medical research2023

miR-6076 rs1463411 polymorphisms are associated with bleeding during clopidogrel treatment in patients with acute coronary syndrome.

Zhen-Zhen Mo, Zhen Yuan, Yuan-Yuan Peng, Wan-Lu Zhou, Wei Dai, Guo Wang, Jie Tang, Wei Zhang, Bi-Lian Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhen-Zhen MoDepartment of Geriatrics, National Geriatrics Clinic Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China.
Zhen YuanDepartment of Geriatrics, National Geriatrics Clinic Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China.
Yuan-Yuan PengDepartment of Geriatrics, National Geriatrics Clinic Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China.
Wan-Lu ZhouDepartment of Geriatrics, National Geriatrics Clinic Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China.
Wei DaiDepartment of Geriatrics, National Geriatrics Clinic Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China.
Guo WangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, People's Republic of China.
Jie TangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, People's Republic of China.
Wei ZhangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, 410008, People's Republic of China.
Bi-Lian ChenDepartment of Geriatrics, National Geriatrics Clinic Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China. 1281373573@qq.com.ORCID http://orcid.org/0000-0002-3573-0615
Central South University · CN

Funding

Changsha Science and Technology Bureau, Hunan province, China kq2202367Hunan Provincial Health Commission, Hunan province, China 20201525Science and Technology Department of Hunan Province 2021JJ31094Science and Technology Department of Hunan Province 2021JJ31099Science and Technology Department of Hunan Province 2022JJ70156
6 · The paper itself

Abstract

Bleeding is a major adverse event during clopidogrel treatment in patients with acute coronary syndrome (ACS). However, the potential mechanism affecting bleeding among individuals is unclear. Herein, we investigated the involvement of CYP2C19*2 and CYP2C19*3, as well as 10 miRNA polymorphisms, in bleeding in Chinese patients with ACS during the first year of clopidogrel treatment. The miR-6076 rs1463411 G polymorphism was significantly associated with the risk of bleeding (P < 0.001), and the rs1463411 GT + GG genotype significantly increased the risk of bleeding (adjusted odds ratio, 6.09; 95% confidence interval, 1.09-34.0; P < 0.001). Dual luciferase assay showed that miR-6076 significantly decreased the mRNA expression of P2RY12 (P < 0.05). P2RY12 mRNA and protein levels were significantly lower in cells transfected with miR-6076-G than in cells transfected with miR-6076-T (P < 0.05). The findings indicate that miR-6076 targets P2RY12 mRNA and that miR-6076 rs1463411 T/G polymorphisms differentially regulate P2RY12 mRNA and protein levels in cells. rs1463411 G polymorphism may increase the risk of bleeding during clopidogrel treatment in patients with ACS.

Indexed as

Acute Coronary SyndromeMicroRNAsPercutaneous Coronary InterventionClopidogrelCytochrome P-450 CYP2C19GenotypeHemorrhageHumansPlatelet Aggregation InhibitorsTiclopidineTreatment OutcomeClopidogrelCytochrome P-450 CYP2C19MicroRNAsPlatelet Aggregation InhibitorsTiclopidineAcute coronary syndromeBleedingClopidogrelCYP2C19Gene polymorphismmiRNA-6076

Identifiers

PMID36829258
PMCPMC9951409
OpenAlexW4321788836

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.