Evidence map›Paper›PMID 36829230›Full record

ArticleJournal of neuroinflammation2023

Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning.

Chinyere Agbaegbu Iweka, Erica Seigneur, Amira Latif Hernandez, Sur Herrera Paredes, Mica Cabrera, Eran Blacher, Connie Tsai Pasternak, Frank M Longo, Luis de Lecea, Katrin I Andreasson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Chinyere Agbaegbu IwekaDepartment of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA.
Erica SeigneurDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Amira Latif HernandezDepartment of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA.
Sur Herrera ParedesDepartment of Biology, Stanford University, Stanford, CA, USA.
Mica CabreraDepartment of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA.
Eran BlacherDepartment of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA.
Connie Tsai PasternakDepartment of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA.
Frank M LongoDepartment of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA.
Luis de LeceaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Katrin I AndreassonDepartment of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA. kandreas@stanford.edu.
Stanford Medicine · USStanford University · USNational Library of Israel · IL

Funding

Reprogramming myeloid cell metabolism to prevent cognitive aging and Alzheimer's DiseaseRF1AG070839 · NIA · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I. · 2021 to 2021
$1.9M
Outcomes of Sleep Disorders in Older Men- Reading CenterR01HL070839 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI REDLINE, SUSAN S. · 2003 to 2007
$1.2M
NIA NIH HHS RF1 AG070839
6 · The paper itself

Abstract

Aging is associated with loss of circadian immune responses and circadian gene transcription in peripheral macrophages. Microglia, the resident macrophages of the brain, also show diurnal rhythmicity in regulating local immune responses and synaptic remodeling. To investigate the interaction between aging and microglial circadian rhythmicity, we examined mice deficient in the core clock transcription factor, BMAL1. Aging Cd11b

Indexed as

Cognitive AgingMicrogliaAnimalsARNTL Transcription FactorsCLOCK ProteinsMiceNeuronal PlasticityARNTL Transcription FactorsCLOCK ProteinsBMAL1Circadian clockMicrogliaSleep–wake cycleSynaptic plasticity

Identifiers

PMID36829230
PMCPMC9951430
OpenAlexW4321788292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.