Evidence map›Paper›PMID 36828945›Full record

ArticleEuropean journal of nutrition2023

Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men.

Konstantinos Papanikolaou, Athanasios Z Jamurtas, Athanasios Poulios, Panagiotis Tsimeas, Dimitrios Draganidis, Nikos V Margaritelis, Ioannis Baloyiannis, Constantinos Papadopoulos, Apostolos Sovatzidis, Chariklia K Deli and 5 more

Registry-linked trialAbstract read
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In one paragraph

Article in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03711838 (The Effect of Redox Potential on the Regulation of Satellite Cells and Skeletal Muscle Healing Following Exercise-Induced Muscle Damage), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03711838 nacompletednot on this map

The Effect of Redox Potential on the Regulation of Satellite Cells and Skeletal Muscle Healing Following Exercise-Induced Muscle Damage

TypeinterventionalSponsorUniversity of ThessalyRan2019 to 2022Enrolled45ConditionsSatellite Cells, Redox Status, Exercise-induced Muscle Trauma, Aseptic InflammationArmsN-Acetylcysteine, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Characterization of theMolecules (Basel, Switzerland) · 2024
    Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Konstantinos PapanikolaouDepartment of Physical Education and Sports Science, University of Thessaly, 42100, Trikala, Greece.ORCID http://orcid.org/0000-0002-5062-9881
Athanasios Z JamurtasDepartment of Physical Education and Sports Science, University of Thessaly, 42100, Trikala, Greece.ORCID http://orcid.org/0000-0001-5115-9490
Athanasios PouliosDepartment of Physical Education and Sports Science, University of Thessaly, 42100, Trikala, Greece.ORCID http://orcid.org/0000-0003-3912-0045
Panagiotis TsimeasDepartment of Physical Education and Sports Science, University of Thessaly, 42100, Trikala, Greece.ORCID http://orcid.org/0000-0001-5498-3119
Dimitrios DraganidisDepartment of Physical Education and Sports Science, University of Thessaly, 42100, Trikala, Greece.ORCID http://orcid.org/0000-0002-2773-7729
Nikos V MargaritelisDepartment of Physical Education and Sports Science, Aristotle University of Thessaloniki, 62110, Serres, Greece.ORCID http://orcid.org/0000-0001-5119-427X
Ioannis BaloyiannisDepartment of Surgery, University Hospital of Larissa, School of Medicine, University of Thessaly, 41500, Larissa, Greece.ORCID http://orcid.org/0000-0002-6050-3000
Constantinos PapadopoulosFirst Department of Neurology, Aeginition Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528, Athens, Greece.ORCID http://orcid.org/0000-0001-7633-5032
Apostolos SovatzidisDepartment of Nephrology, University Hospital of Alexandroupolis, School of Medicine, Democritus University of Thrace, 68100, Alexandroupolis, Greece.ORCID http://orcid.org/0000-0002-2859-0845
Chariklia K DeliDepartment of Physical Education and Sports Science, University of Thessaly, 42100, Trikala, Greece.ORCID http://orcid.org/0000-0002-5762-8419
Anastasia RosvoglouDepartment of Physical Education and Sports Science, University of Thessaly, 42100, Trikala, Greece.ORCID http://orcid.org/0000-0001-5243-4378
Kalliopi GeorgakouliDepartment of Nutrition and Dietetics, University of Thessaly, 42100, Trikala, Greece.ORCID http://orcid.org/0000-0001-5545-9271
Theofanis TzatzakisDepartment of Physical Education and Sports Science, University of Thessaly, 42100, Trikala, Greece.ORCID http://orcid.org/0000-0002-5690-600X
Michalis G NikolaidisDepartment of Physical Education and Sports Science, Aristotle University of Thessaloniki, 62110, Serres, Greece.
Ioannis G FatourosDepartment of Physical Education and Sports Science, University of Thessaly, 42100, Trikala, Greece. ifatouros@pe.uth.gr.ORCID http://orcid.org/0000-0002-8475-8411
University of Thessaly · GRAristotle University of Thessaloniki · GRDemocritus University of Thrace · GRNational and Kapodistrian University of Athens · GR

Funding

Hellenic Foundation for Research and Innovation HFRI Ph.D. Fellowship grant number 32
6 · The paper itself

Abstract

purposeTo investigate the association between redox status in erythrocytes and skeletal muscle with dietary nutrient intake and markers of physical fitness and habitual physical activity (PA).

methodsForty-five young physically active men were assessed for body composition, dietary nutrient intake, muscle strength, cardiorespiratory capacity and habitual PA. Blood and muscle samples were collected to estimate selected redox biomarkers. Partial correlation analysis was used to evaluate the independent relationship of each factor with redox biomarkers.

resultsDietary cysteine intake was positively correlated (p < 0.001) with both erythrocyte (r = 0.697) and muscle GSH (0.654, p < 0.001), erythrocyte reduced/oxidized glutathione ratio (GSH/GSSG) (r = 0.530, p = 0.001) and glutathione reductase (GR) activity (r = 0.352, p = 0.030) and inversely correlated with erythrocyte protein carbonyls (PC) levels (r = - 0.325; p = 0.046). Knee extensors eccentric peak torque was positively correlated with GR activity (r = 0.355; p = 0.031) while, one-repetition maximum in back squat exercise was positively correlated with erythrocyte GSH/GSSG ratio (r = 0.401; p = 0.014) and inversely correlated with erythrocyte GSSG and PC (r = - 0.441, p = 0.006; r = - 0.413, p = 0.011 respectively). Glutathione peroxidase (GPx) activity was positively correlated with step count (r = 0.520; p < 0.001), light (r = 0.406; p = 0.008), moderate (r = 0.417; p = 0.006), moderate-to-vigorous (r = 0.475; p = 0.001), vigorous (r = 0.352; p = 0.022) and very vigorous (r = 0.326; p = 0.035) PA. Muscle GSSG inversely correlated with light PA (r = - 0.353; p = 0.022).

conclusionThese results indicate that dietary cysteine intake may be a critical element for the regulation of glutathione metabolism and redox status in two different tissues pinpointing the independent significance of cysteine for optimal redox regulation. Musculoskeletal fitness and PA levels may be predictors of skeletal muscle, but not erythrocyte, antioxidant capacity.

trial registrationRegistry: ClinicalTrials.gov, identifier: NCT03711838, date of registration: October 19, 2018.

Indexed as

CysteineGlutathioneAntioxidantsBiomarkersEatingGlutathione DisulfideHumansMaleMuscle, SkeletalOxidation-ReductionOxidative StressPhysical FitnessAntioxidantsBiomarkersCysteineGlutathioneGlutathione DisulfideAntioxidant enzymesCysteineGlutathioneMuscle functionPhysical activityRedox regulation

Identifiers

PMID36828945
OpenAlexW4321781840

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.