Evidence map›Paper›PMID 36828892›Full record

ArticleScientific reports2023

Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions.

Andrea T Obi, Sriganesh B Sharma, Megan A Elfline, Catherine E Luke, Abigail R Dowling, Qing Cai, Andrew S Kimball, Mike Hollinstat, Livia Stanger, Bethany B Moore and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Andrea T ObiConrad Jobst Vascular Research Laboratories, University of Michigan Medical School, Ann Arbor, USA. henke@umich.edu.
Sriganesh B SharmaConrad Jobst Vascular Research Laboratories, University of Michigan Medical School, Ann Arbor, USA.
Megan A ElflineConrad Jobst Vascular Research Laboratories, University of Michigan Medical School, Ann Arbor, USA.
Catherine E LukeConrad Jobst Vascular Research Laboratories, University of Michigan Medical School, Ann Arbor, USA.
Abigail R DowlingConrad Jobst Vascular Research Laboratories, University of Michigan Medical School, Ann Arbor, USA.
Qing CaiConrad Jobst Vascular Research Laboratories, University of Michigan Medical School, Ann Arbor, USA.
Andrew S KimballSection of Vascular Surgery, University of Alabama Division of Vascular Surgery, University of Michigan Medical School, Ann Arbor, USA.
Mike HollinstatDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, USA.
Livia StangerDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, USA.
Bethany B MooreDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, USA.
Farouc A JafferSection of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Peter K HenkeConrad Jobst Vascular Research Laboratories, University of Michigan Medical School, Ann Arbor, USA.
University of Michigan–Ann Arbor · USAnn Arbor VA Medical Center · USHarvard University · US

Funding

Immunobiology of Lung Injury and FibrosisR35HL144481 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOORE, BETHANY B. · 2019 to 2024
$5.2M
The Monocyte/Macrophage Role in Experimental Deep Vein Thrombosis Resolution and Vein Wall InjuryR01HL144550 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K · 2020 to 2023
$2.2M
The Role of IL-6 in Experimental Post Thrombotic SyndromeR01HL132988 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K · 2016 to 2019
$1.9M
Myeloid TLR4 epigenetic regulation and signaling in accelerating venous thrombus resolutionK08HL155408 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OBI, ANDREA TARA · 2021 to 2025
$783k
NHLBI NIH HHS K08 HL155408NHLBI NIH HHS R01 HL132988NHLBI NIH HHS R01 HL144550NHLBI NIH HHS R35 HL144481
6 · The paper itself

Abstract

Deep venous thrombosis and residual thrombus burden correlates with circulating IL-6 levels in humans. To investigate the cellular source and role of IL-6 in thrombus resolution, Wild type C57BL/6J (WT), and IL-6

Indexed as

ThrombosisVascular DiseasesVenous ThrombosisAnimalsDisease Models, AnimalHumansInterleukin-6MiceMice, Inbred C57BLMonocytesVena Cava, InferiorInterleukin-6

Identifiers

PMID36828892
PMCPMC9951841
OpenAlexW4321791552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.