Evidence map›Paper›PMID 36828843›Full record

ArticleCommunications biology2023

Nanowarming and ice-free cryopreservation of large sized, intact porcine articular cartilage.

Peng Chen, Shangping Wang, Zhenzhen Chen, Pengling Ren, R Glenn Hepfer, Elizabeth D Greene, Lia H Campbell, Kristi L Helke, Xingju Nie, Jens H Jensen and 4 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Peng ChenDepartment of Bioengineering, Clemson University, Clemson, SC, USA.ORCID 0000-0002-3883-4671
Shangping WangDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Zhenzhen ChenTissue Testing Technology LLC, North Charleston, SC, USA.
Pengling RenDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
R Glenn HepferDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Elizabeth D GreeneTissue Testing Technology LLC, North Charleston, SC, USA.
Lia H CampbellTissue Testing Technology LLC, North Charleston, SC, USA.
Kristi L HelkeDepartment of Comparative Medicine, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0001-9746-0764
Xingju NieDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0003-4247-8945
Jens H JensenDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0003-3219-4287
Cherice HillDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Yongren WuDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Kelvin G M BrockbankDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Hai YaoDepartment of Bioengineering, Clemson University, Clemson, SC, USA. haiyao@clemson.edu.ORCID 0000-0001-5130-5128
Medical University of South Carolina · USCell and Tissue Systems (United States) · USClemson University · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jian Ouyang · 2009 to 2026
$42.7M
Tissue Structural and Neural Remodeling in Human Sacroiliac JointP20GM121342 · NIGMS · CLEMSON UNIVERSITY · PI Hai Yao · 2018 to 2026
$24.7M
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2012 to 2020
$20.2M
T-COHR: Training in Craniofacial and Oral Health ResearchT32DE017551 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAO, HAI · 2006 to 2025
$10.3M
Integrating craniofacial morphology, oral function, temporomandibular biomechanics and mechanobiology to determine sex-specific TMJ pathophysiology in humansR01DE021134 · NIDCR · CLEMSON UNIVERSITY · PI YAO, HAI · 2012 to 2025
$4.7M
Ice-free vitrification and nanowarming of large osteochondral grafts for transplantationR44AR073136 · NIAMS · TISSUE TESTING TECHNOLOGIES, LLC · PI BROCKBANK, KELVIN G.M. · 2019 to 2020
$1.7M
Confocal/Multiphoton Microscope UpgradeS10OD018113 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J · 2015 to 2015
$570k
Tissue structure and mechanical function relationships of the human temporomandibular lateral capsule-ligament: Investigation of sexual and racial dimorphismsK99DE031345 · NIDCR · CLEMSON UNIVERSITY · PI HILL, CHERICE NATASHA · 2022 to 2023
$215k
NCI NIH HHS P30 CA138313NIAMS NIH HHS R44 AR073136NIDCR NIH HHS K99 DE031345NIDCR NIH HHS R01 DE021134NIDCR NIH HHS T32 DE017551NIGMS NIH HHS P20 GM103542NIGMS NIH HHS P20 GM121342NIH HHS S10 OD018113
6 · The paper itself

Abstract

Successful organ or tissue long-term preservation would revolutionize biomedicine. Cartilage cryopreservation enables prolonged shelf life of articular cartilage, posing the prospect to broaden the implementation of promising osteochondral allograft (OCA) transplantation for cartilage repair. However, cryopreserved large sized cartilage cannot be successfully warmed with the conventional convection warming approach due to its limited warming rate, blocking its clinical potential. Here, we develope a nanowarming and ice-free cryopreservation method for large sized, intact articular cartilage preservation. Our method achieves a heating rate of 76.8 °C min

Indexed as

Cartilage, ArticularAnimalsCryopreservationMagnetic Resonance ImagingSwineTissue Preservation

Identifiers

PMID36828843
PMCPMC9958003
OpenAlexW4321791315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.