Evidence map›Paper›PMID 36828670›Full record

ReviewPaediatric respiratory reviews2023

Phylogenomics of nontuberculous mycobacteria respiratory infections in people with cystic fibrosis.

Nicholas Bolden, Joshua Chang Mell, Jennifer Bouso Logan, Paul J Planet

Open access · hybridAbstract readReview
In one paragraph

Review in Paediatric respiratory reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Insights on the Pathogenesis ofJournal of clinical medicine · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Genomic epidemiology ofERJ open research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Nicholas BoldenPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States. Electronic address: ndbolden@pennmedicine.upenn.edu.
Joshua Chang MellCenter for Genomic Sciences, Drexel University College of Medicine, Philadelphia, PA, United States; Department of Microbiology & Immunology, Drexel University, Philadelphia, PA, United States. Electronic address: jcm385@drexel.edu.
Jennifer Bouso LoganDivision of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States; Department of Pulmonary Medicine and Cystic Fibrosis Center, Lehigh Valley Reilly Children's Hospital, PA, United States. Electronic address: jennifer.logan@lvhn.org.
Paul J PlanetPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, United States; Comparative Genomics, American Museum of Natural History, New York, NY, United States. Electronic address: planetp@chop.edu.
Children's Hospital of Philadelphia · USDrexel University · USLehigh Valley Hospital-Pocono · USUniversity of Pennsylvania · US

Funding

In Host Evolution of Nontuberculous Mycobacteria in Cystic FibrosisR21AI144561 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI PLANET, PAUL J · 2020 to 2021
$485k
NIAID NIH HHS R21 AI144561
6 · The paper itself

Abstract

Nontuberculous mycobacteria (NTM) can cause severe pulmonary disease in people with cystic fibrosis (pwCF). These infections present unique challenges for diagnosis and treatment, prompting a recent interest in understanding NTM transmission and pathogenesis during chronic infection. Major gaps remain in our knowledge regarding basic pathogenesis, immune evasion strategies, population dynamics, recombination potential, and the evolutionary implications of host and antibiotic pressures of long-term NTM infections in pwCF. Phylogenomic techniques have emerged as an important tool for tracking global patterns of transmission and are beginning to be used to ask fundamental biological questions about adaptation to the host during pathogenesis. In this review, we discuss the burden of NTM lung disease (NTM-LD), highlight the use of phylogenomics in NTM research, and address the clinical implications associated with these studies.

Indexed as

Cystic FibrosisMycobacterium Infections, NontuberculousRespiratory Tract InfectionsHumansNontuberculous MycobacteriaPhylogenyBacterial evolutionGenomicsNontuberculous mycobacteriaNTMPhylogeny

Identifiers

PMID36828670
PMCPMC10659050
OpenAlexW4319965201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.