Evidence map›Paper›PMID 36828637›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated Na

Benjamin J Smith, Cyrus F McHugh, Arlene A Hirano, Nicholas C Brecha, Steven Barnes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Benjamin J SmithDoheny Eye Institute, University of California, Los Angeles, California 91103.
Cyrus F McHughDoheny Eye Institute, University of California, Los Angeles, California 91103.
Arlene A HiranoDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095.ORCID 0000-0001-8842-3582
Nicholas C BrechaDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095.
Steven BarnesDoheny Eye Institute, University of California, Los Angeles, California 91103 sbarnes@doheny.org.ORCID 0000-0003-0496-1645
University of California, Los Angeles · US

Funding

NEUROCHEMICAL PATHWAYS IN THE INNER RETINAR01EY004067 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRECHA, NICHOLAS C. · 1985 to 2019
$9.0M
Horizontal cell signaling in the mammalian retinaR01EY029869 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRECHA, NICHOLAS C. · 2019 to 2023
$2.8M
Retinal Ganglion Cell Signaling Regulated By Intrinsic Reactive Oxygen SpeciesR01EY033905 · NEI · DOHENY EYE INSTITUTE · PI Steven Andrew Barnes · 2023 to 2026
$1.6M
Mitochondrial reactive oxygen species act as autocrine neuromodulators in retinal ganglion cellsF32EY032401 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMITH, BENJAMIN · 2021 to 2022
$140k
BLRD VA IK6 BX005230NEI NIH HHS F32 EY032401NEI NIH HHS R01 EY004067NEI NIH HHS R01 EY029869NEI NIH HHS R01 EY033905
6 · The paper itself

Abstract

Increasing spike rates drive greater neuronal energy demand. In turn, mitochondrial ATP production leads to the generation of reactive oxygen species (ROS) that can modulate ion channel gating. Does ROS production autoregulate the excitability of a neuron? We investigated the links between retinal ganglion cell (RGC) excitability and spike activity-driven ROS production in male and female mice. Changes to the light-evoked and current-evoked spike patterns of functionally identified αRGC subtypes, along with their Na

Indexed as

Hydrogen PeroxideRetinal Ganglion CellsAnimalsFemaleMaleMiceReactive Oxygen SpeciesRetinaSignal TransductionHydrogen PeroxideReactive Oxygen Speciesaction potentialganglion cellreactive oxygen speciesretinaRGCsodium channel

Identifiers

PMID36828637
PMCPMC10072295
OpenAlexW4321780009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.