ArticleGut2023
Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: a population-based, cross-sectional cohort study.
Article in Gut, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Age-Associated Differences in Ductal Involvement in Biliary Lithiasis: A Consecutive MRCP Cohort Study.Life (Basel, Switzerland) · 2026Article
- Clinico-pathological features and prognosis of mixed-IPMNs with a focal involvement of the main pancreatic duct.Updates in surgery · 2026Article
- Comparative analysis of 3 T versus 1.5 T MRCP image quality and age-stratified biliary normative values in infants.La Radiologia medica · 2026Article
- Postcontrast application of single breath-hold three-dimensional variable flip-angle fast spin-echo breath-hold magnetic resonance cholangiopancreatography for evaluating the pancreaticobiliary ductal system.Quantitative imaging in medicine and surgery · 2026Article
- Post-cholecystectomy Changes in the Common Bile Duct Diameter: A Comparative Ultrasound Study.Cureus · 2026Article
- Common Bile Duct Diameter in Bladder Urothelial Carcinoma: A Case-Control Study.Cancer management and research · 2026Article
- "Evaluation of hepatobiliary disorders using magnetic resonance cholangiopancreatography in a low-resource setting in Kano, Nigeria: a retrospective study".BMC gastroenterology · 2025Article
- Article
- Quantitative MRCP metrics as imaging biomarkers to differentiate benign from malignant bile duct obstructions.Frontiers in oncology · 2025Article
- Scaling a Hydraulic Motor for Minimally Invasive Medical Devices.Micromachines · 2024Article
- Pancreatic ultrasound: An update of measurements, reference values, and variations of the pancreas.Ultrasound international open · 2024Review
- An overview of extrahepatic cholangiocarcinoma: from here to where?Frontiers in oncology · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChanges of the pancreaticobiliary ducts herald disease. Magnetic resonance cholangiopancreatography (MRCP) allows accurate duct visualisation. Data on reliable upper reference ranges are missing.
designCross-sectional whole body MRI data from the population-based Study of Health in Pomerania were analysed. The width of the common bile duct (CBD) and the pancreatic duct (PD) was determined. We aimed to describe the distribution of physiological duct diameters on MRCP in a population of healthy subjects and to identify factors influencing duct size.
resultsAfter excluding pre-existing pancreaticobiliary conditions, CBD and PD diameters from 938 and 774 healthy individuals, respectively, showed a significant increase with age (p<0.0001) and exceeded the conventional upper reference limit of normal in 10.9% and 18.2%, respectively. Age-dependent upper reference limits of duct diameters were delineated with non-parametric quantile regression, defined as 95th percentile: for CBD up to 8 mm in subjects <65 years and up to 11 mm in subjects ≥65 years. For the PD reference diameters were up to 3 mm in subjects <65 years and up to 4 mm in subjects ≥65 years.
conclusionsThis is the first population-based study delineating age-adjusted upper reference limits of CBD and PD on MRCP. We showed that up to 18.2% of healthy volunteers would have needed diagnostic workup, if the conventional reference values were used. The utilisation of the adapted reference levels may help to avoid unnecessary investigations and thus to reduce healthcare expenditure and test-related adverse events.
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