Evidence map›Paper›PMID 36828529›Full record

ArticleTropical medicine and infectious disease2023

Therapeutic Drug Monitoring of Vancomycin Concentrations for the Management of Bone and Joint Infections: An Urgent Need.

Laura Rio-No, Luisa Sorli, Alba Arderiu-Formenti, Marta De Antonio, Lucas Martorell, Isaac Subirana, Lluis Puig, Albert Alier, Joan Gómez-Junyent, Daniel Pérez-Prieto and 1 more

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In one paragraph

Article in Tropical medicine and infectious disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Laura Rio-NoPharmacy Department, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain.
Luisa SorliInfectious Diseases Department, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain.
Alba Arderiu-FormentiPharmacy Department, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain.
Marta De AntonioPharmacy Department, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain.
Lucas MartorellOrthopedic Surgery and Traumatology Department, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain.
Isaac SubiranaCIBER en Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain.
Lluis PuigOrthopedic Surgery and Traumatology Department, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain.
Albert AlierOrthopedic Surgery and Traumatology Department, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain.
Joan Gómez-JunyentInfectious Diseases Department, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain.ORCID 0000-0003-1752-1382
Daniel Pérez-PrietoOrthopedic Surgery and Traumatology Department, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain.
Sonia LuquePharmacy Department, Hospital del Mar, Parc de Salut Mar, 08003 Barcelona, Spain.
Parc de Salut · ESHospital del Mar Research Institute · ESCentro de Investigación en Red en Enfermedades Cardiovasculares · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vancomycin is used for the treatment of bone and joint infections (BJI), but scarce information is available about its pharmacokinetic/pharmacodynamic (PK/PD) characteristics. We aimed to identify the risk factors associated with the non-achievement of an optimal PK/PD target in the first therapeutic drug monitoring (TDM). Methods: A retrospective study was conducted in a tertiary hospital from January 2020 to January 2022. Patients with BJI and TDM of vancomycin on day 2 of treatment were included. Initial vancomycin fixed doses (1 g every 8 h or 12 h) was decided by the responsible doctors. According to TDM results, dosage adjustments were performed. An AUC

Indexed as

bone and joint infectionsdosage regimensnephrotoxicitypharmacokineticstherapeutic drug monitoringvancomycin

Identifiers

PMID36828529
PMCPMC9959361
OpenAlexW4320492218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.