ArticleToxins2023
Advantages of Multiplexing Ability of the Orbitrap Mass Analyzer in the Multi-Mycotoxin Analysis.
Article in Toxins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Critical evaluation of MS acquisition conditions and identification process in LC-Q-Orbitrap-MS for non-targeted analysis: pesticide residues as case of study.Analytical and bioanalytical chemistry · 2023Article
- Review
- Fungal and mycotoxin contaminants in cannabis and hemp flowers: implications for consumer health and directions for further research.Frontiers in microbiology · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In routine measurements, the length of the analysis time and nfumber of samples analysed during a time unit are crucial parameters, which are especially important for the food analysis, particularly in the case of mycotoxin determinations. High-resolution equipment, including time-of-flight or Orbitrap analyzators, can provide stable instrumental background for high-throughput analyses. In this report, a short, 1 min MS-based multi-mycotoxin method was developed with the application of a short column as a reduced chromatographic separation, taking advantages of the multiplexing and high-resolution capability of the QExactive Orbitrap MS possessing sub-1 ppm mass accuracy. The performance of the method was evaluated regarding selectivity, LOD, LOQ, linearity, matrix effect, and recovery, and compared to a UHPLC-MS/MS method. The final multiplexing method was able to quantify 11 mycotoxins in defined ranges (aflatoxins (corn, 2.8-600 μg/kg; wheat, 1.5-350 μg/kg), deoxynivalenol (corn, 640-9600 μg/kg; wheat, 128-3500 μg/kg), fumonisins (corn, 20-1500 μg/kg; wheat, 30-3500 μg/kg), HT-2 (corn, 64-5200 μg/kg; wheat, 61-3500 μg/kg), T-2 (corn, 10-800 μg/kg; wheat, 4-250 μg/kg), ochratoxin (corn, 4.7-600 μg/kg; wheat, 1-1000 μg/kg), zearalenone (corn, 64-4800 μg/kg; wheat, 4-500 μg/kg)) within one minute in corn and wheat matrices at the MRL levels stated by the European Union.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.