Trial reportOphthalmology. Glaucoma
Outcomes of Glaucoma Reoperations in the Primary Tube Versus Trabeculectomy Study.
Trial report in Ophthalmology. Glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study.Ophthalmology · 2024Trial
- Evaluating the outcomes of inferonasal ahmed valve implantation using the double scleral tunnel technique in refractory glaucoma.BMC ophthalmology · 2025Article
- Analysis of resurgeries following primary glaucoma surgical intervention in a tertiary care center.Indian journal of ophthalmology · 2025Observational
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo describe the incidence and outcomes of reoperations for glaucoma in the Primary Tube Versus Trabeculectomy (PTVT) Study.
designCohort study of patients in a multicenter randomized clinical trial.
participantsThe PTVT Study enrolled 242 patients with medically uncontrolled glaucoma and no previous incisional ocular surgery.
methodsRandomization assigned 125 patients to placement of a tube shunt (350-mm
main outcome measuresOutcome measures included intraocular pressure (IOP), use of glaucoma medications, visual acuity, surgical complications, and failure (IOP > 21 mmHg or reduced by <20%, IOP ≤ 5 mmHg, additional glaucoma surgery, or loss of light perception vision).
resultsAdditional glaucoma surgery was performed in 21 patients in the tube group and 12 patients in the trabeculectomy group in the PTVT Study, and the 5-year cumulative reoperation rate for glaucoma was 18.0% in the tube group and 10.4% in the trabeculectomy group (P = 0.15). Follow-up (mean ± standard deviation [SD]) after additional glaucoma surgery was 35.1 ± 17.7 months in the tube group and 30.1 ± 17.6 months in the trabeculectomy group (P = 0.44). At 3 years after glaucoma reoperation, IOP (mean ± SD) was 15.5 ± 4.8 mmHg in the tube group and 16.6 ± 7.3 mmHg in the trabeculectomy group (P = 0.71). The number of glaucoma medications (mean ± SD) after 3 years of follow-up was 2.1 ± 1.7 in the tube group and 1.7 ± 1.0 in the trabeculectomy group (P = 0.58). The cumulative probability of failure at 3 years after a glaucoma reoperation was 37.8% in the tube group and 21.3% in the trabeculectomy group (P = 0.47).
conclusionNo significant difference in the rate of reoperation for glaucoma was observed after tube shunt implantation and trabeculectomy with MMC in the PTVT Study. Similar surgical outcomes were observed after additional glaucoma surgery, irrespective of the initial procedure to which the patient was randomized. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
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