Evidence map›Paper›PMID 36828202›Full record

ArticleAmerican heart journal2023

Clinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial.

Michael G Nanna, Eric Yow, Sreekanth Vemulapalli, Daniel B Mark, Michelle Kelsey, Manesh R Patel, Hussein R Al-Khalidi, Campbell Rogers, James E Udelson, Pamela S Douglas

Abstract readLetter
In one paragraph

Article in American heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael G NannaSection of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT. Electronic address: michael.nanna@yale.edu.
Eric YowDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Sreekanth VemulapalliDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Daniel B MarkDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Michelle KelseyDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Manesh R PatelDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Hussein R Al-KhalidiDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.
Campbell RogersHeartFlow, Inc., Redwood City, CA.
James E UdelsonDivision of Cardiology and the CardioVascular Center, Tufts Medical Center, Boston, MA.
Pamela S DouglasDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Albert C Shaw · 2002 to 2026
$37.9M
Postdoctoral Training in Cardiovascular Clinical ResearchT32HL069749 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2003 to 2023
$6.7M
Generating novel predictive models to estimate the risk of future ASCVD & Dementia in older adultsR03AG074067 · NIA · YALE UNIVERSITY · PI NANNA, MICHAEL · 2021 to 2022
$335k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS T32 HL069749NIA NIH HHS P30 AG021342NIA NIH HHS R03 AG074067
6 · The paper itself

Abstract

Current guidelines recommend a deferred testing approach in low-risk patients presenting with stable chest pain. After simulating a deferred testing approach using the PROMISE Minimal Risk Score to identify 915 minimal risk participants with cost data from the PROMISE trial, a deferred testing strategy was associated with an adjusted cost savings of -$748.74 (95% CI: -1646.97, 158.06) per participant and 74.6% of samples had better clinical outcomes and lower mean cost. This supports the current guideline recommended deferred testing approach in low-risk patients with stable chest pain.

Indexed as

Chest PainCoronary AngiographyHumansRisk Factors

Identifiers

PMID36828202
PMCPMC10903188

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.