Trial reportEndoscopy2023
Endoscopic vacuum therapy for esophageal perforation: a multicenter retrospective cohort study.
Trial report in Endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Endoscopic negative-pressure therapy for anastomotic leaks after upper gastrointestinal surgery: systematic review and meta-analysis.Surgical endoscopy · 2026Pooled it
- EVT-Inspired Simplified Negative-Pressure Nasoesophageal Drainage for Cervical Abscess Secondary to Esophageal Perforation.The American journal of case reports · 2026Article
- Diagnostic Approach and Therapeutic Management of Spontaneous Esophageal Perforation (Boerhaave's Syndrome): A Systematic Review and Individual Patient-Level Pooled Analysis.Journal of clinical medicine · 2026Review
- Stepwise endoscopic and surgical management of spontaneous esophageal rupture with severe mediastinal contamination: A case report.Experimental and therapeutic medicine · 2026Article
- [Esophageal perforation: surgical outcomes in a referral center].Revista medica del Instituto Mexicano del Seguro Social · 2026Article
- Recurrent Cervical Esophageal Fistula and Retroesophageal Abscess Following Surgical Management of Zenker's Diverticulum.Journal of clinical medicine · 2026Article
- T-tube insertion as a salvage procedure for failed primary repair in penetrating esophageal injury complicated by sepsis: a case report from low resource setting.International journal of surgery case reports · 2026Article
- Endoscopic stenting as salvage therapy for high-risk Boerhaave's syndrome patients.Journal of thoracic disease · 2026Article
- Catastrophic Esophageal Tumor Perforation within One Week after First-Line Chemo-Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma: A Case Report.Surgical case reports · 2026Article
- Observational
- Stents and Emerging Alternatives in Upper Gastrointestinal Endoscopy: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2025Review
- Esophageal stenting and endoscopic vacuum therapy for esophageal defects: a systematic review and meta-analysis of observational studies.Annals of medicine and surgery (2012) · 2025Article
- Article
- Article
- Therapeutic Intervention in Pediatric Endoscopy: Management of Postsurgical Complications and Bleeding.Visceral medicine · 2025Review
- Multimodal therapeutic options for esophageal perforations-a single-center experience.Frontiers in surgery · 2025Article
- How to preserve the native or reconstructed esophagus after perforations or postoperative leaks: A multidisciplinary 15-year experience.World journal of gastrointestinal surgery · 2024Article
- Endoscopic vacuum therapy.iGIE : innovation, investigation and insights · 2024Article
- Additional over-the-scope-clip closure can shorten endoscopic vacuum therapy for postoperative upper gastrointestinal leakage.Endoscopy international open · 2024Article
- VAC-Stent in the Treatment of Post-Esophagectomy Anastomotic Leaks: A New "Kid on the Block" Who Marries the Best of Old Techniques-A Review.Journal of clinical medicine · 2024Review
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic vacuum therapy (EVT) is a novel treatment for esophageal perforations. This study aimed to describe initial experience with EVT of esophageal perforations due to iatrogenic cause, Boerhaave syndrome, or other perforations not related to prior upper gastrointestinal surgery.
methodsData from patients treated with EVT for esophageal perforation at five hospitals in three European countries, between January 2018 and October 2021, were retrospectively collected. The primary end point was successful defect closure by EVT, with or without the use of other endoscopic treatment modalities. Secondary end points included mortality and adverse events.
results27 patients were included (median age 71 years). The success rate was 89 % (24/27, 95 %CI 77-100). EVT failed in three patients: two deceased during EVT (septic embolic stroke, pulmonary embolism) and one underwent esophagectomy due to a persisting defect. Two adverse events occurred: one iatrogenic defect expansion during sponge exchange and one hemorrhage during sponge removal. Median treatment duration was 12 days (interquartile range [IQR] 6-16) with 1 sponge exchange (IQR 1-3).
conclusionEVT is a promising organ-preserving treatment for esophageal perforations, with a success rate of 89 %. More experience with the technique and indications will likely improve success rates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.