ArticleCell metabolism2023
Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs.
Article in Cell metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Whole-Brain Connectome Identifies PMvCells · 2026Article
- Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026Review
- Balancing acts: lateral hypothalamic circuits coordinating feeding, anxiety, and social interactions.Reviews in endocrine & metabolic disorders · 2026Review
- Substance P in the lateral hypothalamic area regulates binge-like eating behaviors in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses.Nature neuroscience · 2025Article
- Inhibition of the lateral hypothalamus emboldens adult female spiny mice to huddle with an established group of novel peers.Scientific reports · 2025Article
- Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila.Nature communications · 2025Article
- Influence of the neurotensin signaling system on feeding and satiety.Neuropharmacology · 2025Review
- The interoceptive origin of reinforcement learning.Trends in cognitive sciences · 2025Review
- Review
- Direct interoceptive input to the insular cortex shapes learned feeding behavior.bioRxiv : the preprint server for biology · 2025Article
- Energy state guides reward seeking via an extended amygdala to lateral hypothalamus pathway.Nature communications · 2025Article
- Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles.Experimental & molecular medicine · 2025Review
- The neurobiology of thirst and salt appetite.Neuron · 2024Review
- Interconnected neural circuits mediating social reward.Trends in neurosciences · 2024Review
- A normative framework dissociates need and motivation in hypothalamic neurons.Science advances · 2024Article
- Sequential Activation of Lateral Hypothalamic Neuronal Populations during Feeding and Their Assembly by Gamma Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Auditory pallial regulation of the social behavior network.Communications biology · 2024Article
- Wanting to matter and learning to care: A neurodevelopmental window of opportunity for (Pro) social learning?Developmental cognitive neuroscience · 2024Review
- Hypothalamic-hindbrain circuit for consumption-induced fear regulation.Nature communications · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals continuously weigh hunger and thirst against competing needs, such as social contact and mating, according to state and opportunity. Yet neuronal mechanisms of sensing and ranking nutritional needs remain poorly understood. Here, combining calcium imaging in freely behaving mice, optogenetics, and chemogenetics, we show that two neuronal populations of the lateral hypothalamus (LH) guide increasingly hungry animals through behavioral choices between nutritional and social rewards. While increased food consumption was marked by increasing inhibition of a leptin receptor-expressing (LepR
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.