Evidence map›Paper›PMID 36827943›Full record

ArticleNeurobiology of aging2023

Age- and sex-related differences in baboon (Papio anubis) gray matter covariation.

M M Mulholland, A Meguerditchian, W D Hopkins

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M M MulhollandThe University of Texas MD Anderson Cancer Center, Bastrop, TX. Electronic address: mmmulholland@mdanderson.org.
A MeguerditchianLaboratoire de Psychologie Cognitive UMR7290, LPC, CNRS, Aix-Marseille University, Institute of Language, Communication and the Brain, Marseille, France; Station de Primatologie-Celphedia, UAR846, Rousset, France.
W D HopkinsThe University of Texas MD Anderson Cancer Center, Bastrop, TX.

Funding

Specific Pathogen Free Baboon Research Resource (SPFBRR) - Bridge Funding Administrative SupplementP40OD024628 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Joe H. Simmons · 2017 to 2026
$15.7M
Alzheimer's Disease Pathology in a Primate ModelR01AG067419 · NIA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HOPKINS, WILLIAM D · 2021 to 2025
$3.8M
Baboon model of chemotherapy-related cognitive impairment and accelerated agingK01AG078411 · NIA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Michele M Mulholland · 2022 to 2026
$941k
NIA NIH HHS K01 AG078411NIA NIH HHS R01 AG067419NIH HHS P40 OD024628
6 · The paper itself

Abstract

Age-related changes in cognition, brain morphology, and behavior are exhibited in several primate species. Baboons, like humans, naturally develop Alzheimer's disease-like pathology and cognitive declines with age and are an underutilized model for studies of aging. To determine age-related differences in gray matter covariation of 89 olive baboons (Papio anubis), we used source-based morphometry (SBM) to analyze data from magnetic resonance images. We hypothesized that we would find significant age effects in one or more SBM components, particularly those which include regions influenced by age in humans and other nonhuman primates (NHPs). A multivariate analysis of variance revealed that individual weighted gray matter covariation scores differed across the age classes. Elderly baboons contributed significantly less to gray matter covariation components including the brainstem, superior parietal cortex, thalamus, and pallidum compared to juveniles, and middle and superior frontal cortex compared to juveniles and young adults (p < 0.05). Future studies should examine the relationship between the changes in gray matter covariation reported here and age-related cognitive decline.

Indexed as

Gray MatterPapio anubisAgedAnimalsBrainCerebral CortexHumansMagnetic Resonance ImagingPapioAgingBaboonGray matter covariationNonhuman primateSource-based morphometry

Identifiers

PMID36827943
PMCPMC10308318

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.