Evidence map›Paper›PMID 36827708›Full record

ArticleBiomedical materials (Bristol, England)2023

Bone marrow stromal cells generate an osteoinductive microenvironment when cultured on titanium-aluminum-vanadium substrates with biomimetic multiscale surface roughness.

Michael B Berger, D Joshua Cohen, Kyla B Bosh, Marina Kapitanov, Paul J Slosar, Michael M Levit, Michelle Gallagher, Jeremy J Rawlinson, Zvi Schwartz, Barbara D Boyan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical materials (Bristol, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Michael B BergerDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 W. Main Street, Richmond, VA 23284, United States of America.
D Joshua CohenDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 W. Main Street, Richmond, VA 23284, United States of America.
Kyla B BoshDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 W. Main Street, Richmond, VA 23284, United States of America.
Marina KapitanovDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 W. Main Street, Richmond, VA 23284, United States of America.
Paul J SlosarSpineCare Medical Group, 455 Hickey Blvd., Suite 310, Daly City, CA 94015, United States of America.
Michael M LevitDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 W. Main Street, Richmond, VA 23284, United States of America.
Michelle GallagherMedtronic, Applied Research-Spine, Minneapolis, MN, United States of America.
Jeremy J RawlinsonMedtronic, Applied Research-Spine, Minneapolis, MN, United States of America.
Zvi SchwartzDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 W. Main Street, Richmond, VA 23284, United States of America.
Barbara D BoyanDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, 601 W. Main Street, Richmond, VA 23284, United States of America.ORCID 0000-0002-9642-0311
Virginia Commonwealth University · USMedtronic (United States) · USCardiovascular Medical Group · USGeorgia Institute of Technology · USThe University of Texas Health Science Center at San Antonio · US

Funding

Mechanisms Mediating Osseointegration of 3D Printed Titanium ConstructsR01AR072500 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI BOYAN, BARBARA D. · 2019 to 2023
$2.9M
NIAMS NIH HHS R01 AR072500
6 · The paper itself

Abstract

Osseointegration of titanium-based implants possessing complex macroscale/microscale/mesoscale/nanoscale (multiscale) topographies support a direct and functional connection with native bone tissue by promoting recruitment, attachment and osteoblastic differentiation of bone marrow stromal cells (MSCs). Recent studies show that the MSCs on these surfaces produce factors, including bone morphogenetic protein 2 (BMP2) that can cause MSCs not on the surface to undergo osteoblast differentiation, suggesting they may produce an osteogenic environment

Indexed as

Mesenchymal Stem CellsTitaniumAlloysAluminumAnimalsBenzophenonesBiomimeticsCell DifferentiationCells, CulturedCytokinesDNAInterleukin-10Interleukin-4Interleukin-6MiceMice, NudeAlloysAluminumBenzophenonesCytokinesDNAInterleukin-10Interleukin-4Interleukin-6polyetheretherketonePolyethylene GlycolsPolymersTitaniumtitanium alloy (TiAl6V4)VanadiumBMP2mouse in vivo modelnanoroughnessosseointegrationosteoblastsosteoinductiontitanium

Identifiers

PMID36827708
PMCPMC9993812
OpenAlexW4321765925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.