Evidence map›Paper›PMID 36827526›Full record

ArticleThe journal of physical chemistry. B2023

Machine Learning Guided Design of High-Affinity ACE2 Decoys for SARS-CoV-2 Neutralization.

Matthew C Chan, Kui K Chan, Erik Procko, Diwakar Shukla

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matthew C ChanDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61081, United States.ORCID 0000-0002-9826-1983
Kui K ChanCyrus Biotechnology, Inc., Seattle, Washington 98101, United States.
Erik ProckoCyrus Biotechnology, Inc., Seattle, Washington 98101, United States.
Diwakar ShuklaDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61081, United States.ORCID 0000-0003-4079-5381
University of Illinois Urbana-Champaign · USCyrus Biotechnology

Funding

Elucidating sequence, structural and dynamic basis of the functional regulation of membrane proteinsR35GM142745 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SHUKLA, DIWAKAR · 2021 to 2025
$1.8M
Optimization of a broad and potent decoy receptor for SARS-associated virusesR43AI162329 · NIAID · ORTHOGONAL BIOLOGICS, INC. · PI CHAN, KUI KIU · 2021 to 2021
$257k
NIAID NIH HHS R43 AI162329NIGMS NIH HHS R35 GM142745
6 · The paper itself

Abstract

A potential therapeutic strategy for neutralizing SARS-CoV-2 infection is engineering high-affinity soluble ACE2 decoy proteins to compete for binding to the viral spike (S) protein. Previously, a deep mutational scan of ACE2 was performed and has led to the identification of a triple mutant variant, named sACE2

Indexed as

COVID-19SARS-CoV-2AlgorithmsAngiotensin-Converting Enzyme 2HumansMachine LearningMutationProtein BindingAngiotensin-Converting Enzyme 2

Identifiers

PMID36827526
PMCPMC9999943
OpenAlexW4321765711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.