ArticlePloS one2023
Sex differences in long-term survival after intensive care unit treatment for sepsis: A cohort study.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Experimental robustness and reproducibility of the murine cecal ligation and puncture sepsis model.Intensive care medicine experimental · 2026Article
- Health-Related Quality of Life and Mobility Levels in ICU Survivors with Heel Pressure Ulcer: An Observational Study.Nursing reports (Pavia, Italy) · 2026Article
- Sex differences in sepsis outcomes across the lifespan: a population-based cohort study in Germany.Critical care (London, England) · 2025Article
- Raman Spectroscopy Can Identify Acute and Persistent Biochemical Changes in Leukocytes From Patients With COVID-19 and Non-COVID-19-Associated Sepsis.Biotechnology journal · 2025Article
- Decreased racial disparities in sepsis mortality after an order set-driven initiative: An analysis of 8151 patients.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025Article
- POSTINJURY PNEUMONIA INDUCES A UNIQUE BLOOD MICROBIOME SIGNATURE.Shock (Augusta, Ga.) · 2024Article
- Estrogen receptor subtype mediated anti-inflammation and vasorelaxationFrontiers in endocrinology · 2023Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the effect of sex on sepsis-related ICU admission and survival for up to 3-years.
methodsRetrospective cohort study of adults admitted to Australian ICUs between 2018 and 2020. Men and women with a primary diagnosis of sepsis were included. The primary outcome of time to death for up to 3-years was examined using Kaplan Meier plots. Secondary outcomes included the duration of ICU and hospital stay.
resultsOf 523,576 admissions, there were 63,039 (12·0%) sepsis-related ICU admissions. Of these, there were 50,956 patients (43·4% women) with 3-year survival data. Men were older (mean age 66·5 vs 63·6 years), more commonly received mechanical ventilation (27·4% vs 24·7%) and renal replacement therapy (8·2% vs 6·8%) and had worse survival (Hazard Ratio [HR] 1·11; 95% Confidence Interval [CI] 1·07 to 1·14, P<0·001) compared to women. The duration of hospital and ICU stay was longer for men, compared to women (median hospital stay, 9.8 vs 9.4 days; p<0.001 and ICU stay, 2.7 vs 2.6 days; p<0.001).
conclusionMen are more likely to be admitted to ICU with sepsis and have worse survival for up to 3-years. Understanding causal mechanisms of sex differences may facilitate the development of targeted sepsis strategies.
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