Evidence map›Paper›PMID 36827208›Full record

ArticleMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention2022

Sparse Interpretation of Graph Convolutional Networks for Multi-Modal Diagnosis of Alzheimer's Disease.

Houliang Zhou, Yu Zhang, Brian Y Chen, Li Shen, Lifang He

Abstract read
In one paragraph

Article in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. A functional system-informed graph neural network framework to quantify interpretable brain dysfunction in ASD.Neural networks : the official journal of the International Neural Network Society · 2026
    Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Houliang ZhouDepartment of Computer Science and Engineering, Lehigh University, PA, USA.
Yu ZhangDepartment of Bioengineering, Lehigh University, PA, USA.
Brian Y ChenDepartment of Computer Science and Engineering, Lehigh University, PA, USA.
Li ShenDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, PA, USA.
Lifang HeDepartment of Computer Science and Engineering, Lehigh University, PA, USA.

Funding

Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Artificial Intelligence Strategies for Alzheimer's Disease ResearchU01AG066833 · NIA · CEDARS-SINAI MEDICAL CENTER · PI MOORE, JASON H., RITCHIE, MARYLYN D · 2022 to 2025
$6.7M
Artificial Intelligence Strategies for Alzheimer's Disease ResearchR01AG066833 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H., RITCHIE, MARYLYN D · 2021 to 2021
$1.6M
Informatics Algorithms for Genomic Analysis of Brain Imaging DataR01LM013463 · NLM · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H., SAYKIN, ANDREW J · 2020 to 2023
$1.4M
NIA NIH HHS R01 AG066833NIA NIH HHS U01 AG066833NIA NIH HHS U01 AG068057NLM NIH HHS R01 LM013463
6 · The paper itself

Abstract

The interconnected quality of brain regions in neurological disease has immense importance for the development of biomarkers and diagnostics. While Graph Convolutional Network (GCN) methods are fundamentally compatible with discovering the connected role of brain regions in disease, current methods apply limited consideration for node features and their connectivity in brain network analysis. In this paper, we propose a sparse interpretable GCN framework (SGCN) for the identification and classification of Alzheimer's disease (AD) using brain imaging data with multiple modalities. SGCN applies an attention mechanism with sparsity to identify the most discriminative subgraph structure and important node features for the detection of AD. The model learns the sparse importance probabilities for each node feature and edge with entropy,

Indexed as

Graph convolutional networkMulti-ModalityNeuroimagingSparse interpretation

Identifiers

PMID36827208
PMCPMC9942706

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.