Evidence map›Paper›PMID 36827156›Full record

ArticleMarine drugs2023

Fucoidan from

Noelia Flórez-Fernández, Jorge F Pontes, Filipa Guerreiro, Inês T Afonso, Giovanna Lollo, Maria Dolores Torres, Herminia Domínguez, Ana M Rosa da Costa, Ana Grenha

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
7.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 23 citations in OpenAlex.

  1. Foods (Basel, Switzerland) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Noelia Flórez-FernándezDrug Delivery Laboratory, Centre for Marine Sciences (CCMAR), Faculty of Sciences and Technology, Universidade do Algarve, 8005-139 Faro, Portugal.ORCID 0000-0002-2666-2315
Jorge F PontesDrug Delivery Laboratory, Centre for Marine Sciences (CCMAR), Faculty of Sciences and Technology, Universidade do Algarve, 8005-139 Faro, Portugal.ORCID 0000-0002-6447-0242
Filipa GuerreiroDrug Delivery Laboratory, Centre for Marine Sciences (CCMAR), Faculty of Sciences and Technology, Universidade do Algarve, 8005-139 Faro, Portugal.
Inês T AfonsoDrug Delivery Laboratory, Centre for Marine Sciences (CCMAR), Faculty of Sciences and Technology, Universidade do Algarve, 8005-139 Faro, Portugal.
Giovanna LolloUniversity of Lyon, Université Claude Bernard Lyon 1, LAGEPP CNRS, UMR 5007, 69622 Villeurbanne, France.ORCID 0000-0001-7030-3056
Maria Dolores TorresCINBIO, Universidade de Vigo, 32004 Ourense, Spain.ORCID 0000-0001-6811-1290
Herminia DomínguezCINBIO, Universidade de Vigo, 32004 Ourense, Spain.ORCID 0000-0002-6475-3242
Ana M Rosa da CostaAlgarve Chemistry Research Center (CIQA) and Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, Universidade do Algarve, 8005-139 Faro, Portugal.ORCID 0000-0003-0225-9537
Ana GrenhaDrug Delivery Laboratory, Centre for Marine Sciences (CCMAR), Faculty of Sciences and Technology, Universidade do Algarve, 8005-139 Faro, Portugal.ORCID 0000-0002-2136-1396
University of Algarve · PTUniversidade de Vigo · ESUniversité Claude Bernard Lyon 1 · FRUniversity of Lisbon · PT

Funding

European Union European Regional Development Fund - ERDF - Ref. ED431G2019/06Fundação para a Ciência e Tecnologia LA/P/0101/2020Fundação para a Ciência e Tecnologia UIDB/04326/2020Fundação para a Ciência e Tecnologia UID/Multi/04326/2020Fundação para a Ciência e Tecnologia UIDP/04326/2020PHC Pessoa Programme between ANR and Fundação para a Ciência e Tecnologia NanoSpeed, (N◦42306YB)Xunta de Galicia Centro Singular de Investigación de Galicia accreditation 2019-2022Xunta de Galicia ED431F 2020/01
6 · The paper itself

Abstract

The composition of seaweeds is complex, with vitamins, phenolic compounds, minerals, and polysaccharides being some of the factions comprising their structure. The main polysaccharide in brown seaweeds is fucoidan, and several biological activities have been associated with its structure. Chitosan is another marine biopolymer that is very popular in the biomedical field, owing to its suitable features for formulating drug delivery systems and, particularly, particulate systems. In this work, the ability of fucoidan to produce nanoparticles was evaluated, testing different amounts of a polymer and using chitosan as a counterion. Nanoparticles of 200-300 nm were obtained when fucoidan prevailed in the formulation, which also resulted in negatively charged nanoparticles. Adjusting the pH of the reaction media to 4 did not affect the physicochemical characteristics of the nanoparticles. The IC

Indexed as

ChitosanFucusNanoparticlesSeaweedPolysaccharidesSulfatesChitosanfucoidanPolysaccharidesSulfatesantioxidantcell proliferationchitosanfucoidanFucus vesiculosusnanoparticlesrheology

Identifiers

PMID36827156
PMCPMC9966594
OpenAlexW4319601945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.