Evidence map›Paper›PMID 36827135›Full record

ArticleMarine drugs2023

Isolation and Characterization of NpCI, a New Metallocarboxypeptidase Inhibitor from the Marine Snail

Aymara Cabrera-Muñoz, Yusvel Sierra-Gómez, Giovanni Covaleda-Cortés, Mey L Reytor, Yamile González-González, José M Bautista, Francesc Xavier Avilés, Maday Alonso-Del-Rivero

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Aymara Cabrera-MuñozCentro de Estudio de Proteínas, Facultad de Biología, Universidad de la Habana, La Habana 10400, Cuba.ORCID 0000-0002-8208-2446
Yusvel Sierra-GómezCentro de Estudio de Proteínas, Facultad de Biología, Universidad de la Habana, La Habana 10400, Cuba.
Giovanni Covaleda-CortésInstitut de Biotecnologia i de Biomedicina and Departament de Bioquímica, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID 0000-0002-7621-852X
Mey L ReytorCentro de Estudio de Proteínas, Facultad de Biología, Universidad de la Habana, La Habana 10400, Cuba.
Yamile González-GonzálezCentro de Estudio de Proteínas, Facultad de Biología, Universidad de la Habana, La Habana 10400, Cuba.
José M BautistaDepartamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain.ORCID 0000-0001-8926-881X
Francesc Xavier AvilésInstitut de Biotecnologia i de Biomedicina and Departament de Bioquímica, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.ORCID 0000-0002-1399-6789
Maday Alonso-Del-RiveroCentro de Estudio de Proteínas, Facultad de Biología, Universidad de la Habana, La Habana 10400, Cuba.ORCID 0000-0003-1988-6852
University of Havana · CUUniversitat Autònoma de Barcelona · ESUniversidad Complutense de Madrid · ES

Funding

Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo 210RT0390
6 · The paper itself

Abstract

Metallocarboxypeptidases are zinc-dependent peptide-hydrolysing enzymes involved in several important physiological and pathological processes. They have been a target of growing interest in the search for natural or synthetic compound binders with biomedical and drug discovery purposes, i.e., with potential as antimicrobials or antiparasitics. Given that marine resources are an extraordinary source of bioactive molecules, we screened marine invertebrates for new inhibitory compounds with such capabilities. In this work, we report the isolation and molecular and functional characterization of NpCI, a novel strong metallocarboxypeptidase inhibitor from the marine snail

Indexed as

AntimalarialsCarboxypeptidasesPlasmodium falciparumAnimalsCattleHumansProteinsSnailsSwineAntimalarialsCarboxypeptidasesProteinsantimalarialcarboxypeptidase inhibitormarine invertebratemetallocarboxipeptidasesPlasmodium falciparumslow- and tight-binding inhibitor

Identifiers

PMID36827135
PMCPMC9966942
OpenAlexW4318485495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.