Evidence map›Paper›PMID 36826911›Full record

ArticleJournal of functional biomaterials2023

Synthesis and Spectral Characterisation of Fabricated Cerium-Doped Magnesium Oxide Nanoparticles: Evaluation of the Antimicrobial Potential and Its Membranolytic Activity through Large Unilamellar Vesicles.

Ashapurna Khatua, Kajal Kumari, Deepak Khatak, Annesha Roy, Neelima Bhatt, Bernard Paul, Aparupa Naik, Amiya Kumar Patel, Uttam Kumar Panigrahi, Santosh Kumar Sahu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of functional biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 20 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Ashapurna KhatuaSchool of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Kajal KumariA.I. Virtanen Institute for Molecular Sciences, Univerisity of Eastern Finland, 70211 Kuopio, Finland.
Deepak KhatakSchool of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India.ORCID 0000-0003-1630-9734
Annesha RoySchool of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Neelima BhattSchool of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Bernard PaulInstitut Jules Guyot, University of Bourgogne, 21000 Dijon, France.ORCID 0000-0002-1262-4051
Aparupa NaikSchool of Biotechnology and Bioinformatics, Sambalpur University, Odisha 757003, India.
Amiya Kumar PatelSchool of Biotechnology and Bioinformatics, Sambalpur University, Odisha 757003, India.
Uttam Kumar PanigrahiDepartment of Physics, Maharaja Sriram Chandra Bhanja Deo University, Odisha 757003, India.
Santosh Kumar SahuDepartment of Physics, Maharaja Sriram Chandra Bhanja Deo University, Odisha 757003, India.
Muthupandian SaravananAMR and Nanotherapeutics Lab, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 600077, India.ORCID 0000-0002-1480-3555
Ramovatar MeenaSchool of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India.ORCID 0000-0002-3703-3274
Jawaharlal Nehru University · INMaharaja Sriram Chandra Bhanja Deo University · INSambalpur University · INSaveetha University · INUniversity of Eastern Finland · FI

Funding

University Grants Commission UGC-BSR Start-Up Grant (F30-433/2018)
6 · The paper itself

Abstract

Considerable attention has been given to Magnesium oxide nanoparticles lately due to their antimicrobial potential, low toxicity to humans, high thermal stability, biocompatibility, and low cost of production. However, their successful transformation into sustainable drugs is limited due to their low membrane permeability, which reduces their bioavailability in target cells. Herein we propose Cerium-doped magnesium oxide nanoparticles (MgOCeNPs) as a powerful solution to above mentioned limitations and are compared with MgO NPs for their membrane permeability and antimicrobial activity. Both pure and Ce-doped were characterized by various spectroscopic and microscopic techniques, in which an X-ray diffraction (XRD) examination reveals the lattice patterns for doped nanoparticles. Furthermore, Atomic Force Microscopy (AFM) revealed the three-dimensional (3D) structure and height of the nanoparticle. The crystal structure (FCC) of MgO did not change with Ce doping. However, microstructural properties like lattice parameter, crystallite size and biological activity of MgO significantly changed with Ce doping. In order to evaluate the antimicrobial potential of MgOCeNPs in comparison to MgO NPs and to understand the underlying mechanisms, the antibacterial activity was investigated against human pathogenic bacteria

Indexed as

antimicrobial activitycerium doped in magnesium oxide (MgOCeNPs)membrane permeabilityreactive oxygen species

Identifiers

PMID36826911
PMCPMC9966552
OpenAlexW4321377078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.