Evidence map›Paper›PMID 36826895›Full record

ArticleJournal of functional biomaterials2023

3D-Printed GelMA/PEGDA/F127DA Scaffolds for Bone Regeneration.

Jianpeng Gao, Ming Li, Junyao Cheng, Xiao Liu, Zhongyang Liu, Jianheng Liu, Peifu Tang

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
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  6. Article
  7. Gelatin Methacrylate Macroporous Cell Scaffold Fabrication via One-Pot Aqueous Two-Phase Separation.Journal of biomedical materials research. Part B, Applied biomaterials · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jianpeng GaoDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing 100039, China.
Ming LiDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing 100039, China.
Junyao ChengDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing 100039, China.
Xiao LiuDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing 100039, China.
Zhongyang LiuDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing 100039, China.
Jianheng LiuDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing 100039, China.
Peifu TangDepartment of Orthopaedics, Chinese PLA General Hospital, Beijing 100039, China.

Funding

Beijing Municipal Natural Science Foundation L202033 and L212050the Key Program of National Natural Science Foundation of China 21935011the Military Medical Science and Technology Youth Training Program 19QNP052the Youth Innovation Promotion Association CAS 2019031
6 · The paper itself

Abstract

Tissue-engineered scaffolds are an effective method for the treatment of bone defects, and their structure and function are essential for bone regeneration. Digital light processing (DLP) printing technology has been widely used in bone tissue engineering (BTE) due to its high printing resolution and gentle printing process. As commonly used bioinks, synthetic polymers such as polyethylene glycol diacrylate (PEGDA) and Pluronic F127 diacrylate (F127DA) have satisfactory printability and mechanical properties but usually lack sufficient adhesion to cells and tissues. Here, a compound BTE scaffold based on PEGDA, F127DA, and gelatin methacrylate (GelMA) was successfully prepared using DLP printing technology. The scaffold not only facilitated the adhesion and proliferation of cells, but also effectively promoted the osteogenic differentiation of mesenchymal stem cells in an osteoinductive environment. Moreover, the bone tissue volume/total tissue volume (BV/TV) of the GelMA/PEGDA/F127DA (GPF) scaffold in vivo was 49.75 ± 8.50%, higher than the value of 37.10 ± 7.27% for the PEGDA/F127DA (PF) scaffold and 20.43 ± 2.08% for the blank group. Therefore, the GPF scaffold prepared using DLP printing technology provides a new approach to the treatment of bone defects.

Indexed as

biomaterialsbone regenerationbone tissue engineeringdigital light processing

Identifiers

PMID36826895
PMCPMC9962173

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.