ArticleInsights into imaging2023
Diffusion tensor imaging discriminates focal cortical dysplasia from normal brain parenchyma and differentiates between focal cortical dysplasia types.
Article in Insights into imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The "chapeau de gendarme" sign in focal epilepsy: A systematic review.Epileptic disorders : international epilepsy journal with videotape · 2025Pooled it
- Structural and Quantitative MRI Signal Features in Pediatric Focal Cortical Dysplasia: Clinical Relevance.Physiological research · 2026Article
- Beyond structural MRI: combined diffusion metric improve delineation of epileptogenic tissue in focal cortical dysplasia.Scientific reports · 2026Article
- Arterial spin labeling performs comparably to 2-[Epilepsia · 2026Article
- Evaluating the image quality and brain microstructural exploration of mean apparent propagator-MRI-a pilot study.BMC medical imaging · 2026Article
- Combining interictal and ictal low-density EEG source imaging to delineate the epileptogenic zone in young children.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Advanced neuroimaging in pediatric epilepsy surgery: state of the art and future perspectives.Neuroradiology · 2026Review
- Analysis of cortical dysplasias using b-tensor encoding diffusion MRI in an animal model.PloS one · 2026Article
- Microstructural Analysis of Whole-Brain Changes Increases the Detection of Pediatric Focal Cortical Dysplasia.Diagnostics (Basel, Switzerland) · 2025Article
- Interictal EEG spikes increase perfusion in low-grade epilepsy-associated tumors: a pediatric arterial spin labeling study.La Radiologia medica · 2025Article
- Diagnostic accuracy of T2-hypointensity in determining the epileptogenic lesion on unmyelinated brain MRI in infants with tuberous sclerosis complex (TSC).Brain communications · 2025Article
- Long-term trends in total administered radiation dose from brain [European journal of nuclear medicine and molecular imaging · 2025Article
- Advances in magnetic resonance imaging for the assessment of paediatric focal epilepsy: a narrative review.Translational pediatrics · 2024Review
- Lesion volume and spike frequency on EEG impact perfusion values in focal cortical dysplasia: a pediatric arterial spin labeling study.Scientific reports · 2024Article
- Functional profile of perilesional gray matter in focal cortical dysplasia: an fMRI study.Frontiers in neuroscience · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough diffusion tensor imaging (DTI) may facilitate the identification of cytoarchitectural changes associated with focal cortical dysplasia (FCD), the predominant aetiology of paediatric structural epilepsy, its potential has thus far remained unexplored in this population. Here, we investigated whether DTI indices can differentiate FCD from contralateral brain parenchyma (CBP) and whether clinical features affect these indices.
methodsIn this single-centre, retrospective study, we considered children and adolescents with FCD-associated epilepsy who underwent brain magnetic resonance (MRI), including DTI. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity, and radial diffusivity, were calculated in both FCD and CBP. The DTI indices best discriminating between FCD and CBP were subsequently used to assess the link between DTI and selected clinical and lesion-related parameters.
resultsWe enrolled 32 patients (20 male; median age at MRI 4 years), including 15 with histologically confirmed FCD. FA values were lower (p = 0.03), whereas MD values were higher in FCD than in CBP (p = 0.04). The difference in FA values between FCD and CBP was more pronounced for a positive vs. negative history of status epilepticus (p = 0.004). Among histologically confirmed cases, the difference in FA values between FCD and CBP was more pronounced for type IIb versus type I FCD (p = 0.03).
conclusionsFA and MD discriminate between FCD and CBP, while FA differentiates between FCD types. Status epilepticus increases differences in FA, potentially reflecting changes induced in the brain. Our findings support the potential of DTI to serve as a non-invasive biomarker to characterise FCD in the paediatric population.
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