Intra-Individual Comparison of Sinus and Ectopic Beats Probing the Ventricular Gradient's Activation Dependence.

Resi M Schoonderwoerd, Mariëlle Dik, Sumche Man, Arie C Maan, J Wouter Jukema, Cees A Swenne

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Article in Journal of cardiovascular development and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Resi M SchoonderwoerdCardiology Department, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Mariëlle DikCardiology Department, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Sumche ManCardiology Department, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Arie C MaanCardiology Department, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

J Wouter JukemaCardiology Department, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Cees A SwenneCardiology Department, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-9801-2760

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wilson assumed that the ventricular gradient (VG) is independent of the ventricular activation order. This paradigm has often been refuted and was never convincingly corroborated. We sought to validate Wilson's concept by intra-individual comparison of the VG of sinus beats and ectopic beats, thus assessing the effects of both altered ventricular conduction (caused by the ectopic focus) and restitution (caused by ectopic prematurity). We studied standard diagnostic ECGs of 118 patients with accidental extrasystoles: normally conducted supraventricular ectopic beats (SN, N = 6) and aberrantly conducted supraventricular ectopic beats (SA, N = 20) or ventricular ectopic beats (V, N = 92). In each patient, we computed the VG vectors of the predominant beat, VGp→, of the ectopic beat, VGe→, and of the VG difference vector, ΔVGep→, and compared their sizes. VGe→ of the SA and V ectopic beats were significantly larger than VGp→ (53.7 ± 25.0 vs. 47.8 ± 24.6 mV∙ms, respectively;

Indexed as

action potential duration restitutionextrasystolesintraventricular conductionspatial ventricular gradientvectorcardiogram

Identifiers

PMID36826585

DOI10.3390/jcdd10020089

PMCPMC9964972

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