Evidence map›Paper›PMID 36826531›Full record

ArticleJournal of cardiovascular development and disease2023

Dissecting the Spectrum of Stroke Risk Factors in an Apparently Healthy Population: Paving the Roadmap to Primary Stroke Prevention.

Daniela Efremova, Dumitru Ciolac, Eremei Zota, Danu Glavan, Natalia Ciobanu, Wolfgang Aulitzky, Anna Maria Nics, Eugen Trinka, Chiaki Yamada, Alexandru Movila and 1 more

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniela EfremovaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, Moldova.ORCID 0000-0001-8299-3832
Dumitru CiolacDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, Moldova.ORCID 0000-0003-1243-313X
Eremei ZotaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, Moldova.
Danu GlavanDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, Moldova.
Natalia CiobanuDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, Moldova.
Wolfgang AulitzkyOpen Medical Institute, American Austrian Foundation, 5020 Salzburg, Austria.
Anna Maria NicsOpen Medical Institute, American Austrian Foundation, 5020 Salzburg, Austria.
Eugen TrinkaDepartment of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Centre for Cognitive Neuroscience, 5020 Salzburg, Austria.
Chiaki YamadaDepartment of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, IN 46202, USA.
Alexandru MovilaDepartment of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, IN 46202, USA.
Stanislav A GroppaDepartment of Neurology, Institute of Emergency Medicine, 2004 Chisinau, Moldova.

Funding

Impact of Acid Ceramidase Activity on MIF-mediated migration of circulating osteoclast precursors to periodontal bone lesions in relation to agingR01AG064003 · NIA · NOVA SOUTHEASTERN UNIVERSITY · PI MOVILA, ALEXANDRU · 2019 to 2022
$1.8M
Roles of Periodontal Bacteria-Derived Dihydroceramides in Alzheimer's Disease Exacerbated by Down SyndromeK02AG068595 · NIA · NOVA SOUTHEASTERN UNIVERSITY · PI MOVILA, ALEXANDRU · 2020 to 2024
$908k
NIA NIH HHS K02 AG068595NIA NIH HHS R01 AG064003NIA NIH HHS R01AG-064003, K02AG-068595
6 · The paper itself

Abstract

We aimed to investigate, for the first time, the spectrum of stroke risk factors specific to the population of the Republic of Moldova. The subjects were examined according to a pre-established protocol of risk factor estimation. The study involved 300 subjects, including 60% women and 40% men, with a mean age of 49.9 ± 14.5 years. The most common risk factor was abdominal obesity, identified in 75% of subjects; general obesity was detected in 48%, while 32% of subjects were overweight and 20% were normally weighted. Hypertension was observed in 44%; 8% of those examined had atrial fibrillation, and 9% had diabetes mellitus. Left myocardial hypertrophy on ECG was present in 53% of subjects, and acute ischemic changes in 2%. Laboratory observations detected that glycosylated hemoglobin increased by 7%, and >50% had dyslipidemia. Total cholesterol was significantly elevated by 58%, LDL-cholesterol was increased by 32%, and HDL-cholesterol was decreased by 9%. Homocysteine was increased in 55% and high-sensitivity C-reactive protein in 28% of subjects. These results indicate the presence of modifiable risk factors and the necessity to elaborate on the primary prevention strategies aimed at minimizing the burden of stroke in the population of the Republic of Moldova.

Indexed as

cerebrovascular diseaseepidemiologypreventionrisk factors

Identifiers

PMID36826531
PMCPMC9965290

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.