ArticleBrain structure & function2023
Amygdala lesions are associated with improved mood after epilepsy surgery.
Article in Brain structure & function, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Empathy motivation is preserved following amygdala damage.Brain : a journal of neurology · 2026Article
- Hallucinations during bipolar depressive episode treated with bupropion after alcohol withdrawal surgery: a case report.Frontiers in psychiatry · 2026Article
- The case for hemispheric lateralization of the human amygdala in fear processing.Molecular psychiatry · 2025Article
- Lesion and lesion network localization of dysnomia after epilepsy surgery.Brain : a journal of neurology · 2025Article
- Psychiatric changes after stereotactic laser amygdalohippocampotomy for medial temporal lobe epilepsy.Epilepsy & behavior : E&B · 2023Article
- Unilateral amygdala ablation: a potential treatment option for severe chronic post-traumatic stress disorder (PTSD)?Expert review of neurotherapeutics · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neuroimaging studies in healthy and clinical populations strongly associate the amygdala with emotion, especially negative emotions. The consequences of surgical resection of the amygdala on mood are not well characterized. We tested the hypothesis that amygdala resection would result in mood improvement. In this study, we evaluated a cohort of 52 individuals with medial temporal lobectomy for intractable epilepsy who had resections variably involving the amygdala. All individuals achieved good post-surgical seizure control and had pre- and post-surgery mood assessment with the Beck Depression Inventory (BDI) ratings. We manually segmented the surgical resection cavities and performed multivariate lesion-symptom mapping of change in BDI. Our results showed a significant improvement in average mood ratings from pre- to post-surgery across all patients. In partial support of our hypothesis, resection of the right amygdala was significantly associated with mood improvement (r = 0.5, p = 0.008). The lesion-symptom map also showed that resection of the right hippocampus and para-hippocampal gyrus was associated with worsened post-surgical mood. Future studies could evaluate this finding prospectively in larger samples while including other neuropsychological outcome measures.
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Registered trials
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