Evidence map›Paper›PMID 36826472›Full record

ArticleArchives of toxicology2023

Metabolic signature of HepaRG cells exposed to ethanol and tumor necrosis factor alpha to study alcoholic steatohepatitis by LC-MS-based untargeted metabolomics.

Elias Iturrospe, Rani Robeyns, Katyeny Manuela da Silva, Maria van de Lavoir, Joost Boeckmans, Tamara Vanhaecke, Alexander L N van Nuijs, Adrian Covaci

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Elias IturrospeToxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium. elias.iturrospe@uantwerpen.be.ORCID http://orcid.org/0000-0001-8572-5905
Rani RobeynsToxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-3695-3490
Katyeny Manuela da SilvaToxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0001-5036-6471
Maria van de LavoirToxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0001-7316-3319
Joost BoeckmansDepartment of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Jette, Belgium.ORCID http://orcid.org/0000-0001-8399-5872
Tamara VanhaeckeDepartment of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Jette, Belgium.ORCID http://orcid.org/0000-0002-6685-7299
Alexander L N van NuijsToxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-9377-6160
Adrian CovaciToxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium. adrian.covaci@uantwerpen.be.ORCID http://orcid.org/0000-0003-0527-1136
University of Antwerp · BEVrije Universiteit Brussel · BE

Funding

Fonds Wetenschappelijk Onderzoek 1120623NFonds Wetenschappelijk Onderzoek 1161620NUniversiteit Antwerpen BOF DOCPRO 4 - Antigoon ID 36893Universiteit Antwerpen BOF-GOA - PS ID 41667
6 · The paper itself

Abstract

Despite the high prevalence of alcoholic liver disease, its identification and characterization remain poor, especially in early stages such as alcoholic fatty liver disease and alcoholic steatohepatitis. This latter implies diagnostic difficulties, few therapeutic options and unclear mechanisms of action. To elucidate the metabolic alterations and pinpoint affected biochemical pathways, alcoholic steatohepatitis was simulated in vitro by exposing HepaRG cells to ethanol (IC

Indexed as

Fatty Liver, AlcoholicNon-alcoholic Fatty Liver DiseaseChromatography, LiquidEthanolHumansLiverMetabolomicsTandem Mass SpectrometryTriglyceridesTumor Necrosis Factor-alphaEthanolTriglyceridesTumor Necrosis Factor-alphaAlcoholAlcoholic liver diseaseHepatocytesHepatotoxicityHigh-resolution mass spectrometryLipidomics

Identifiers

PMID36826472
OpenAlexW4321749125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.