Evidence map›Paper›PMID 36826290›Full record

ReviewGels (Basel, Switzerland)2023

The Application of Hyaluronic Acid Injections in Functional and Aesthetic Andrology: A Narrative Review.

Nicolò Schifano, Paolo Capogrosso, Gabriele Antonini, Sara Baldini, Fabrizio Scroppo, Andrea Salonia, Nicola Zerbinati, Federico Dehò

Open access · goldAbstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nicolò SchifanoASST Sette Laghi-Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy.ORCID 0000-0003-4828-4316
Paolo CapogrossoASST Sette Laghi-Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy.
Gabriele AntoniniASST Sette Laghi-Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy.
Sara BaldiniASST Sette Laghi-Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy.
Fabrizio ScroppoASST Sette Laghi-Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy.
Andrea SaloniaDepartment of Urology, Università Vita-Salute San Raffaele, 20132 Milan, Italy.
Nicola ZerbinatiASST Sette Laghi-Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy.
Federico DehòASST Sette Laghi-Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy.ORCID 0000-0002-0453-5710
Ospedale di Circolo e Fondazione Macchi · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyaluronic acid (HA) is a glycosaminoglycan widely utilised in different fields of medicine. We aimed to provide a comprehensive overview of the scientific evidence on the use of HA in andrology. A review of the literature to identify pertinent studies concerning the use of HA in andrology was carried out on the Medline, EMBASE, and the Cochrane databases, with no time restriction up to December 2022. Penile girth enlargement (PGE) using HA proved to be safe and effective in enhancing the diameter of the penis, with durable and satisfactory outcomes in long-term follow-up. Injection of HA in the glans seems to represent an alternative treatment option for those patients with premature ejaculation (PE) who fail to respond to conventional medications. HA intra-plaque injections represent a valid option which may contribute to restore sexual activity in patients with Peyronie's disease (PD). The adoption of HA filler injections should always be tailored to the patient's peculiar anatomy and underlying condition. More robust evidence is required to achieve a uniformed consensus regarding the use of HA in andrology, and further efforts should continue to improve the current injection techniques and HA products.

Indexed as

hyaluronic acidpenile girth enlargementPeyronie’s diseasepremature ejaculation

Identifiers

PMID36826290
PMCPMC9957416
OpenAlexW4318832573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.