ReviewGels (Basel, Switzerland)2023
Recent Advances in Hydrogels via Diels-Alder Crosslinking: Design and Applications.
Review in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Engineered Injectable Hydrogel Platform for Tailoring the Osteoarthritis Microenvironment.Advanced healthcare materials · 2026Review
- Diels-Alder Click Chemistry as a Dynamic-Covalent Crosslinking Method in Spheroid-Encapsulating Hydrogels for Cartilage Engineering.Advanced healthcare materials · 2026Article
- Design and Characterization of Gelatin-Based Interpenetrating Polymer Networks for Biomedical Use: Rheological, Thermal, and Physicochemical Evaluation.Materials (Basel, Switzerland) · 2026Article
- Quantitative Prediction of Stress Relaxation Kinetics in Dissociative Covalent Adaptable Networks.Macromolecules · 2025Article
- Functional Hydrogels in Food Applications: A Review of Crosslinking Technologies, Encapsulation Trends, and Emerging Challenges.Polymers · 2025Review
- Engineering Robust, Porous Guar Gum Hydrogels by One-Step Mild Synthesis: Impact of Porogen Choice on Rheology and Sustained Gastroretentive Amoxicillin Delivery.Gels (Basel, Switzerland) · 2025Article
- Click Chemistry-Based Hydrogels for Tissue Engineering.Gels (Basel, Switzerland) · 2025Review
- Self-Healing, Electroconductive Hydrogels for Wound Healing Applications.Gels (Basel, Switzerland) · 2025Review
- One-pot synthesis of thermally reversible materials using maleimide-polysaccharide and furan-lignin derivatives.RSC advances · 2025Article
- Cellulose-Based Hybrid Hydrogels for Tissue Engineering Applications: A Sustainable Approach.Gels (Basel, Switzerland) · 2025Review
- Review
- Chitosan-Based Gel Development: Extraction, Gelation Mechanisms, and Biomedical Applications.Gels (Basel, Switzerland) · 2025Review
- Focused Ultrasound-Mediated Release of Bone Morphogenetic Protein 2 from Hydrogels for Bone Regeneration.Gels (Basel, Switzerland) · 2025Article
- Photo-crosslinked Diels-Alder and thiol-ene polymer networks.RSC advances · 2025Article
- Chemical Modification of Nanocrystalline Cellulose for Manufacturing of Osteoconductive Composite Materials.Polymers · 2024Article
- A Comprehensive Review of Hydrogel-Based Drug Delivery Systems: Classification, Properties, Recent Trends, and Applications.AAPS PharmSciTech · 2024Review
- Article
- Wound Gel with Antimicrobial Effects Based on Polyvinyl Alcohol and Functional Aryloxycyclotriphosphazene.Polymers · 2023Article
- Self-healing hydrogel as an injectable implant: translation in brain diseases.Journal of biomedical science · 2023Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The Diels-Alder (DA) reaction is a promising tool for obtaining covalently crosslinked hydrogels due to its reaction bioorthogonality, the absence of by-products, and the application of mild conditions without a catalyst. The resulting hydrogels are in demand for use in various fields of materials science and biomedicine. While the dynamic nature of the cycloaddition of diene and dienophile has previously been used extensively for the fabrication of self-healing materials, it has only recently spread to the expansion of the functional properties of polymer gels for bioapplications. This review describes strategies and recent examples of obtaining hydrogels based on the DA reaction, demonstrating that the emerging functional properties go beyond self-healing. The types of classifications of hydrogels are listed, depending on the type of reaction and the nature of the components. Examples of obtaining hydrogels based on the normal and inverse electron-demand DA reaction, as well as the application of hydrogels for cell culture, drug delivery, injectable gels, and wound dressings, are considered. In conclusion, possible developmental directions are discussed, including the use of diene-dienophile pairs with a low temperature for the reversal of DA reaction, the modification of nanoparticles by diene and/or dienophile fragments, and new applications such as ink for 3D printing, sensing hydrogels, etc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.