Evidence map›Paper›PMID 36826226›Full record

ArticleACS infectious diseases2023

Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci.

Louisa J Stewart, YoungJin Hong, Isabel R Holmes, Samantha J Firth, Yasmin Ahmed, Janet Quinn, Yazmin Santos, Steven L Cobb, Nicholas S Jakubovics, Karrera Y Djoko

Open access · hybridFull text read
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Exploring the Healing Powers of Histatins: From Oral Health to Therapeutics.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Louisa J StewartDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom.
YoungJin HongDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom.
Isabel R HolmesDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom.
Samantha J FirthDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom.
Yasmin AhmedBiosciences Institute, Newcastle University, Newcastle NE2 4HH, United Kingdom.
Janet QuinnBiosciences Institute, Newcastle University, Newcastle NE2 4HH, United Kingdom.
Yazmin SantosDepartment of Chemistry, Durham University, Durham DH1 3LE, United Kingdom.
Steven L CobbDepartment of Chemistry, Durham University, Durham DH1 3LE, United Kingdom.ORCID 0000-0002-3790-7023
Nicholas S JakubovicsSchool of Dental Sciences, Newcastle University, Newcastle NE2 4BW, United Kingdom.
Karrera Y DjokoDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom.ORCID 0000-0001-9814-6515
Durham University · GBNewcastle University · GB

Funding

Biotechnology and Biological Sciences Research CouncilWellcome TrustWellcome Trust 214930/Z/18/ZWellcome Trust 215599/Z/19/Z
6 · The paper itself

Abstract

Histatin-5 (Hst5) is a member of the histatin superfamily of cationic, His-rich, Zn(II)-binding peptides in human saliva. Hst5 displays antimicrobial activity against fungal and bacterial pathogens, often in a Zn(II)-dependent manner. In contrast, here we showed that under

Indexed as

Antimicrobial PeptidesHistatinsSalivary Proteins and PeptidesHumansStreptococcusZincAntimicrobial PeptidesHistatinsHTN3 protein, humanSalivary Proteins and PeptidesZincantimicrobial peptidehistatinnutritional immunityStreptococcuszinc

Identifiers

PMID36826226
PMCPMC10012264
OpenAlexW4321748262

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read45
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.