Evidence map›Paper›PMID 36826079›Full record

ArticleCurrent oncology (Toronto, Ont.)2023

Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer.

Grigorios Christodoulidis, Laura J Halliday, Athina Samara, Neel Bhuva, Won-Ho Edward Park, Krishna Moorthy

Abstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Multimodal prehabilitation in digestive oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  6. Review
  7. Article
  8. Nutritional management during chemotherapy and chemoradiotherapy for advanced esophageal cancer.Esophagus : official journal of the Japan Esophageal Society · 2025
    Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Grigorios ChristodoulidisGeneral Surgery Department, University Hospital of Larisa, 41110 Larisa, Greece.
Laura J HallidayDepartment of Surgery and Cancer, Imperial College London, London W2 1NS, UK.
Athina SamaraGeneral Surgery Department, University Hospital of Larisa, 41110 Larisa, Greece.ORCID 0000-0002-6177-7281
Neel BhuvaMount Vernon Cancer Centre, East and North Hertfordshire NHS Trust, Northwood HA6 2RN, UK.
Won-Ho Edward ParkImperial College Healthcare NHS Trust, London W2 1NS, UK.
Krishna MoorthyDepartment of Surgery and Cancer, Imperial College London, London W2 1NS, UK.ORCID 0000-0001-8960-465X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrehabilitation programmes aim to optimise patients before and after cancer treatment including surgery. Previous studies in surgical patients demonstrate that prehabilitation improves pre-operative fitness and overcomes the negative impact of neoadjuvant chemotherapy on fitness. The aim of this study was to assess the impact of prehabilitation on the tolerance of neoadjuvant chemotherapy in patients with oesophageal cancer.

methodsPatients with oesophageal or gastroesophageal junction (GOJ) cancer from two oncology centres were retrospectively included in the present comparative cohort study; one provided a multimodal prehabilitation programme and one did not offer any prehabilitation. Tolerance of chemotherapy, defined as completion of the full chemotherapy regime as per protocol, was compared between the two groups.

resultsIn terms of participants, 92 patients were included in this study, 47 patients in the prehabilitation cohort and 45 in the control cohort. Compared with the control group, the prehabilitation group demonstrated an improved rate of chemotherapy completion (

conclusionThe findings of this exploratory study suggest that prehabilitation is associated with better tolerance for chemotherapy. Further research is needed to establish the long-term impact of prehabilitation on oncological outcomes.

Indexed as

Esophageal NeoplasmsStomach NeoplasmsCohort StudiesHumansPreoperative CarePreoperative ExerciseRetrospective Studieschemotherapygastroesophageal junction canceroesophageal cancerprehabilitationradiotherapy

Identifiers

PMID36826079
PMCPMC9955115

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.