ArticleCurrent issues in molecular biology2023
HLA-C Genotyping Reveals Haplotype C*07 as a Potential Biomarker of Late Psoriasis Onset in Moroccan Patients.
Chaimaa Benlabsir, Myriam Riyad, Imane El Idrissi Saik, Hanaa Ettayebi, Oussama Aazzane, Kawtar Nassar, Soukaina Zaher, Siham Bennani, Brahim Admou, Samy Housbane and 3 more
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In one paragraphArticle in Current issues in molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0 citing papers in PubMed, 4 citations in OpenAlex.
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5 · Who and what moneyAuthors and funding
13 authors at 5 institutions in 1 country.
Chaimaa BenlabsirLaboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco.
Myriam RiyadLaboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco.
Imane El Idrissi SaikLaboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco.ORCID 0000-0002-8348-0307 Hanaa EttayebiLaboratory of Immunology, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco.
Oussama AazzaneLaboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco.
Kawtar NassarRheumatology Department, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco.
Soukaina ZaherRheumatology Department, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco.
Siham BennaniHLA Typing Laboratory, Pasteur Institute of Morocco, Casablanca 20000, Morocco.
Brahim AdmouLaboratory of Immunology, Center of Clinical Research, University Hospital Mohammed VI, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh 40000, Morocco.ORCID 0000-0003-3255-8220 Samy HousbaneLaboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco.ORCID 0000-0002-3973-9123 Khalid SadkiOral Biotechnology Laboratory, Fundamental Sciences Department, Faculty of Dental Medicine, Mohammed V University, Rabat 10000, Morocco.ORCID 0000-0002-9224-5050 Soumiya ChihebLaboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco.
Hassan FellahLaboratory of Cellular and Molecular Pathology, Research Team on Immunopathology of Infectious and Systemic Diseases, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20000, Morocco.ORCID 0000-0001-6778-0484 University of Hassan II Casablanca · MACentre Hospitalier Universitaire Ibn Rochd · MACadi Ayyad University · MAInstitut Pasteur du Maroc · MAMohammed V University · MA
Funding
This study was funded by the research budget allocated to the Cellular and Molecular Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca (Morocco). none
6 · The paper itselfAbstract
Psoriasis still has an unknown etiology. Genetic predisposition shows the association between HLA-Cw6 allele and psoriasis. Although biotherapies have been proven effective in psoriasis treatment, methotrexate (MTX) is still used as a first-line systemic therapy due to its efficacy/affordability, but the differential response to MTX is mostly related to interindividual genetic variability and remains an issue. Our study aimed to analyze HLA-C allele frequencies in a sample of Moroccan psoriatic patients and assess the therapeutic response to MTX. Whole blood of 54 Moroccan psoriatic patients was collected and DNA was extracted. Patients' HLA-C locus was genotyped by PCR-SSO. Results were analyzed with Luminex xMAP Technology and Match-it DNA Evolution 3.4. HLA-C typing results of 77 sex- and age-matched unrelated non-psoriatic healthy subjects were included. We observed no difference in the allelic distribution of HLA-C between patients and healthy controls, suggesting that none of the HLA-C alleles were significantly associated with psoriasis. Moreover, the HLA-C*07 allele was associated with a late age at disease onset (>30 years old) (
Indexed as
HLA-C allelemethotrexatepsoriasis
Identifiers
PMID36826011
PMCPMC9955500
OpenAlexW4318052417
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