ArticleEpilepsia open2023
Potential role of FKBP5 single-nucleotide polymorphisms in functional seizures.
Article in Epilepsia open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Salivary oxytocin and amygdalar alterations in functional neurological disorders.Brain communications · 2025Article
- Biomarkers and Rehabilitation for Functional Neurological Disorder.Journal of personalized medicine · 2024Review
- Polymorphism of glucocorticoid receptor gene (rs41423247) in functional seizures (psychogenic nonepileptic seizures/attacks).Epilepsia open · 2023Article
- Cannabidiol for functional seizures (psychogenic nonepileptic seizures/attacks) and other stress-associated disorders.Epilepsia open · 2023Article
- Correspondence: FKBP5 blockade may provide a new horizon for the treatment of stress-associated disorders: An in silico study.Epilepsia open · 2023Article
- Article
- FKBP5 blockade may provide a new horizon for the treatment of stress-associated disorders: An in-silico study.Epilepsia open · 2023Article
- Potential role of FKBP5 single-nucleotide polymorphisms in functional seizures.Epilepsia open · 2023Article
- Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery.Frontiers in psychiatry · 2023Review
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe investigated the associations between FKBP5 single-nucleotide polymorphisms (SNPs) and functional seizures (FS).
methodsSeventy patients with FS, 140 with major depressive disorder (MDD), and 140 healthy controls were studied. Their DNAs were analyzed for the rs1360780 in the 3' region and rs9470080 in the 5' region of the FKBP5. Childhood trauma questionnaire and hospital anxiety and depression scale were used.
resultsPatients with FS and those with MDD had less GG and more AA genotypes in both rs9470080 and rs1360780 SNPs compared with those in healthy controls. Similar results were observed for allelic frequencies. There were no significant differences between FS and MDD groups in terms of genotype and allelic frequencies for both SNPs. The results of multinomial logistic regression analysis showed that FKBP5 polymorphisms were not associated with the diagnosis. SIGNIFICANCE: Patients with FS and those with MDD had significantly different genotypes in both rs9470080 and rs1360780 SNPs compared with those in healthy controls. However, it seems that FKBP5 polymorphisms were not associated with FS in the absence of depression. Further genetic investigations of patients with FS may increase our understanding of the neurobiological underpinnings of this condition, but such studies should be large enough and very well designed; they should include a comparison group with depression in addition to a healthy control group.
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