Evidence map›Paper›PMID 36825329›Full record

ArticleObstetrics & gynecology science2023

Effect of vitamin D vaginal suppository on sexual functioning among postmenopausal women: A three-arm randomized controlled clinical trial.

Zinat Sarebani, Venus Chegini, Hui Chen, Ehsan Aali, Monirsadat Mirzadeh, Mohammadreza Abbaspour, Mark D Griffiths, Zainab Alimoradi

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obstetrics & gynecology science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
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  8. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Zinat SarebaniStudents research committee, School of Nursing & Midwifery, University of Technology Sydney, Vltimo, Australia.
Venus CheginiDepartment Obstetrics and Gynecology School of Medicine, University of Technology Sydney, Vltimo, Australia.
Hui ChenSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Vltimo, Australia.
Ehsan AaliSchool of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Monirsadat MirzadehMetabolic disease research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammadreza AbbaspourTargeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Mark D GriffithsPsychology Department, Nottingham Trent University, Nottingham, UK.
Zainab AlimoradiSocial Determinants of Health Research Center, Research Institue for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
University of Technology Sydney · AUMashhad University of Medical Sciences · IRNottingham Trent University · GBQazvin University of Medical Sciences · IRTarget (United States) · US

Funding

Qazvin University of Medical Sciences
6 · The paper itself

Abstract

objectiveVaginal atrophy, the second most common complication of menopause, can lead to sexual dysfunction. This study evaluated the effect of a vitamin D vaginal suppository on sexual functioning in postmenopausal women.

methodsThis three-arm randomized controlled trial was conducted between August 2019 and August 2020. The sample comprised 105 postmenopausal women who were referred to comprehensive health service centers to receive postmenopausal care. The inclusion criteria were as follows: (i) being menopausal for at least 1 year, (ii) being married, (iii) being sexually active, and (iv) having sexual desire. Participants were randomly assigned to three groups for 8 weeks of treatment: intervention (vaginal suppository containing 1,000 units of vitamin D3), placebo (vaginal suppository placebo), or control (no treatment). The main outcome measure was sexual functioning, which was assessed using the Female Sexual Function Scale (FSFI) 4 times during the study (i.e., 1 month before the intervention, immediately after the intervention, 1 month after the intervention, and 2 months after the intervention).

resultsImmediately and 1 month after the trial, the intervention group had the highest FSFI score, followed by the placebo group, both of which were significantly higher than those of the control group (P<0.05). At the 2-month follow-up, the intervention and placebo groups had similar FSFI scores (P=0.08), both of which were significantly higher than those in the control group (P=0.001 and P=0.03, respectively).

conclusionVitamin D vaginal suppositories were more effective at improving sexual functioning among postmenopausal women in the short-term and appeared to prevent aging-related sexual functioning decline in the long term.

Indexed as

Postmenopausal period, womenSexual functionVaginal suppositoryVitamin D

Identifiers

PMID36825329
PMCPMC10191758
OpenAlexW4321748744

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.